• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Editorial Staff
    • Publication Ethics
    • Indexing and Abstracting
    • Related Links
    • FAQ
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter Telegram
Asian Pacific Journal of Cancer Prevention
Articles in Press
Current Issue
Journal Archive
Volume Volume 19 (2018)
Volume Volume 18 (2017)
Issue Issue 12
Issue Issue 11
Issue Issue 10
Issue Issue 9
Issue Issue 8
Issue Issue 7
Issue Issue 6
Issue Issue 5
Issue Issue 4
Issue Issue 3
Issue Issue 2
Issue Issue 1
Volume Volume 17 (2016)
Volume Volume 16 (2015)
Volume Volume 15 (2014)
Volume Volume 14 (2013)
Volume Volume 13 (2012)
Volume Volume 12 (2011)
Volume Volume 11 (2010)
Volume Volume 10 (2009)
Volume Volume 9 (2008)
Volume Volume 8 (2007)
Volume Volume 7 (2006)
Volume Volume 6 (2005)
Volume Volume 5 (2004)
Volume Volume 4 (2003)
Volume Volume 3 (2002)
Volume Volume 2 (2001)
Volume Volume 1 (2000)
ebrahimifar, M., Hasanzadegan roudsari, M., Kazemi, S., Ebrahimi Shahmabadi, H., Kanaani, L., Alavi, S., Izadi Vasfi, M. (2017). Enhancing Effects of Curcumin on Cytotoxicity of Paclitaxel, Methotrexate and Vincristine in Gastric Cancer Cells. Asian Pacific Journal of Cancer Prevention, 18(1), 65-68. doi: 10.22034/APJCP.2017.18.1.65
meysam ebrahimifar; Majid Hasanzadegan roudsari; S Maryam Kazemi; Hasan Ebrahimi Shahmabadi; Leila Kanaani; S.A. Alavi; Mehdi Izadi Vasfi. "Enhancing Effects of Curcumin on Cytotoxicity of Paclitaxel, Methotrexate and Vincristine in Gastric Cancer Cells". Asian Pacific Journal of Cancer Prevention, 18, 1, 2017, 65-68. doi: 10.22034/APJCP.2017.18.1.65
ebrahimifar, M., Hasanzadegan roudsari, M., Kazemi, S., Ebrahimi Shahmabadi, H., Kanaani, L., Alavi, S., Izadi Vasfi, M. (2017). 'Enhancing Effects of Curcumin on Cytotoxicity of Paclitaxel, Methotrexate and Vincristine in Gastric Cancer Cells', Asian Pacific Journal of Cancer Prevention, 18(1), pp. 65-68. doi: 10.22034/APJCP.2017.18.1.65
ebrahimifar, M., Hasanzadegan roudsari, M., Kazemi, S., Ebrahimi Shahmabadi, H., Kanaani, L., Alavi, S., Izadi Vasfi, M. Enhancing Effects of Curcumin on Cytotoxicity of Paclitaxel, Methotrexate and Vincristine in Gastric Cancer Cells. Asian Pacific Journal of Cancer Prevention, 2017; 18(1): 65-68. doi: 10.22034/APJCP.2017.18.1.65

Enhancing Effects of Curcumin on Cytotoxicity of Paclitaxel, Methotrexate and Vincristine in Gastric Cancer Cells

Article 11, Volume 18, Issue 1, January 2017, Page 65-68  XML PDF (288 K)
Document Type: Research Articles
DOI: 10.22034/APJCP.2017.18.1.65
Authors
meysam ebrahimifar1; Majid Hasanzadegan roudsari2; S Maryam Kazemi3; Hasan Ebrahimi Shahmabadi4; Leila Kanaani1; S.A. Alavi5; Mehdi Izadi Vasfi 6
1Department of Toxicology, Faculty of Pharmacy, Islamic Azad University, Shahreza Branch, Shahreza
2Department of chemical Engineering, Science and Research branch, Islamic Azad University, Tehran, Iran.
3Department of Genetics, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
4Department of Microbiology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
5Hakiman-e-Shargh Investigative Corporation, Isfahan Science and Technology Town, Isfahan, Iran
6Department of Chemical Engineering, Faculty of Pharmacy, Islamic Azad University, Shahreza, Iran
Receive Date: 20 September 2016,  Revise Date: 24 December 2016,  Accept Date: 09 February 2017 
Abstract
 
Curcumin (Diferuloylmethane), a polyphenolic compound with antioxidant, anti-inflammatory and anticancer properties, has been found to increase chemotherapeutic agents-induced cytotoxicity in some resistant cancer cell lines. This investigation aimed to study the effects of curcumin on efficacy of some common anticancer agents in gastric cancer cells. AGS cells were cultured in RPMI-1640 medium under standard culture conditions (5% CO2 and 95% humidified air at 37°C). Curcumin was used at concentrations of 5, 15, 30 and 50 μM. Cells were treated with a combination of curcumin and paclitaxel (300 nm) or methotrexate (100 μm) or vincristine (5 nm). Cell viability, the percentage of live cells in the whole population, was evaluated by MTT assay after 48 hours. The results showed that cell viability was significantly decreased after incubation of AGS cells with curcumin. Combination with curcumin (15-50 μm) significantly increased cytotoxicity of all three agents (P<0.001). Regarding high anticancer potential and enhancement of chemotherapeutic agent-induced cytotoxicity, the combined use of curcumin with standard chemotherapy of gastric cancer is suggested as a strategy for better management of this fatal cancer.
Keywords
curcumin; Gastric cancer; chemotherapy
Main Subjects
Clinical pharmacology
Statistics
Article View: 644
PDF Download: 630
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

 



 

Journal Management System. Designed by sinaweb.