Evaluation Expression of Microrna-93 and Integrin Β8 in Different Types of Glioma Tumors

Document Type: Research Articles

Authors

1 Neuroscience Research Center ,Institue of Neuropharmacology ,Kerman University of Medical Sciences, Keramn, Iran

2 Department of medical Microbiology ,Kerman university of medical sciences , kerman, Iran

3 Neuroscience Research Center ,Institue of Neuropharmacology,Kerman university of medical sciences , kerman, Iran

4 Pathology and Stem Cell Research Center, Kerman, Iran

Abstract

 
MicroRNAs (miRNAs), are a type of small non-coding RNAs, that induce mRNA degradation or repress translation by binding to the 3′-untranslated region (UTR) of its target mRNA. Some specific miRNAs, e.g. miR-93, have been discovered to be involved in pathological procedures by targeting some oncogenes or tumor suppressors in glioma. In the present study, real-time RT-PCR data was indicated the expression pattern and prognostic value of miR-93 in patients with types of Glioma.MiR-93 expression was significantly decreased in tumor tissue compared with normal group brain tissues (P<0.001). Low miR-93 expression was significantly correlated with progressive tumor grade (P=0.02).Moreover, multivariate analysis showed that miR-93 decreased expression (HR, 4.3; 95% CI, 0.8–17.2, P=0.02), advanced tumor grade (HR, 3.1; 95% CI, 0.2–13.9, P=0.04), for integrinβ8, level expression was inverse. Our data was shown that the down regulation of miR-93 was significantly correlated with unfavorable pathological features in patients with Glioma .Suggesting that decreased expression of miR-93can be used as a novel prognostic factor for this disease.

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