Aim: Abnormal expression pattern ofBetatubulin isotypesmay provide a molecular rationalefor thebehaviour of lymphoma subtypes. The study assessed class II and III Beta-tubulin expression in non-neoplastic and neoplastic lymphoid tissues. Their differential expressions may have diagnostic implications and potential usefulness in the development of new tumour biomarkers. Methods& results: This cross-sectional study investigated class II and III Beta-tubulin expression in 304 neoplastic and 20 normal lymphoid tissues using qualitatively and semi-quantitatively immunohistochemistry. Class II Beta-tubulin was expressed in the germinal centre, mantle zone and interfollicular region of normal lymphoid tissues. Class III Beta-tubulin expression however was germinal centre restricted. Among lymphomas, Class II Beta-tubulin was expressed in 15/15 (100%) lymphoblastic lymphomas, 229/231 (99%) mature B cell lymphomas, 22/22 (100%) T/NK-cell lymphomas and 36/36(100%) classical Hodgkin lymphomas. Class III Beta-tubulin expression however was more selective, found mainly in classical Hodgkin lymphomas (34/36 (94%)). It was also expressed in 58/171(34%) DLBCL, 11/12 (92%) mantle cell lymphomas and 6/6 (100%) Burkitt lymphomas. Other mature B cell, T/NK cell lymphomas and precursor lymphoblastic lymphomas were usually negative. Conclusion:Class II Beta-tubulin shows ubiquitous expression in the neoplastic and non-neoplastic lymphoisd tissues. In contrast, Class III Beta-tubulin expression is germinal centre-restricted. Its consistent expression in classical Hodgkin lymphoma is useful in the identification of Reed-Sternberg and Hodgkin cells. Its expression in a proportion of DLBCL, Burkitt and mantle cell lymphomas is of interest as this may be related to their aggressiveness.
Binti Yusof, N. S., ameli, F., Sabrina Florence, C., Mustangin, M., Abd-Rahman, F., & Masir, N. (2017). Expression of the Class II and III Beta-tubulin in neoplastic and non-neoplastic lymphoid tissues.. Asian Pacific Journal of Cancer Prevention, 18(4), 1045-1050. doi: 10.22034/APJCP.2017.18.4.1045
MLA
Nor Syahida Binti Yusof; fereshteh ameli; Chandramaya Sabrina Florence; Muaatamarulain Mustangin; Faridah Abd-Rahman; Noraidah Masir. "Expression of the Class II and III Beta-tubulin in neoplastic and non-neoplastic lymphoid tissues.". Asian Pacific Journal of Cancer Prevention, 18, 4, 2017, 1045-1050. doi: 10.22034/APJCP.2017.18.4.1045
HARVARD
Binti Yusof, N. S., ameli, F., Sabrina Florence, C., Mustangin, M., Abd-Rahman, F., Masir, N. (2017). 'Expression of the Class II and III Beta-tubulin in neoplastic and non-neoplastic lymphoid tissues.', Asian Pacific Journal of Cancer Prevention, 18(4), pp. 1045-1050. doi: 10.22034/APJCP.2017.18.4.1045
VANCOUVER
Binti Yusof, N. S., ameli, F., Sabrina Florence, C., Mustangin, M., Abd-Rahman, F., Masir, N. Expression of the Class II and III Beta-tubulin in neoplastic and non-neoplastic lymphoid tissues.. Asian Pacific Journal of Cancer Prevention, 2017; 18(4): 1045-1050. doi: 10.22034/APJCP.2017.18.4.1045
)