Background: Angiogenesis plays an essential role in tumor growth and serum levels of YKL-40 , a strong angiogenic factor that promotes tumor vessel development, has been found to be elevated in various cancers. We here investigated correlation between melanoma parameters and serum YKL-40 levels, to assess potential diagnostic, prognostic and predictive values. Material and Methods: Data for 112 pathologically confirmed cutaneous melanomas of any stage were examined retrospectively. ELISA assays were used to measure serum YKL-40 in plasma samples. Results: The baseline serum YKL-40 levels were significantly higher in patients than healthy controls (174.88 vs 120.10 ng/mL, p<0.001). However, values did not correlate with clinicopathological parameters, (p>0.05), and furthermore there was no apparent prognostic influence on melanoma survival (HR: 1.568; 95% CI, 0.580-3.051; p=0.838). Conclusion: Serum YKL-40 can be useful for diagnosis of melanoma, but reliability in assessing prognosis is questionable. We believe that efforts should be made to understand the interaction between YKL-40 and the tumor environment, and establish whether it might be the target for treatment of malignancies.
Erturk, K., Tas, F., Serilmez, M., Bilgin, E., Yasasever, V. (2017). Clinical Signifıcance of Serum Ykl-40 (Chitinase-3-Like-1Protein) as a Biomarker in Melanoma: an Analysis of 112 Turkish Patients. Asian Pacific Journal of Cancer Prevention, 18(5), 1383-1387. doi: 10.22034/APJCP.2017.18.5.1383
MLA
Kayhan Erturk; Faruk Tas; Murat Serilmez; Elif Bilgin; Vildan Yasasever. "Clinical Signifıcance of Serum Ykl-40 (Chitinase-3-Like-1Protein) as a Biomarker in Melanoma: an Analysis of 112 Turkish Patients". Asian Pacific Journal of Cancer Prevention, 18, 5, 2017, 1383-1387. doi: 10.22034/APJCP.2017.18.5.1383
HARVARD
Erturk, K., Tas, F., Serilmez, M., Bilgin, E., Yasasever, V. (2017). 'Clinical Signifıcance of Serum Ykl-40 (Chitinase-3-Like-1Protein) as a Biomarker in Melanoma: an Analysis of 112 Turkish Patients', Asian Pacific Journal of Cancer Prevention, 18(5), pp. 1383-1387. doi: 10.22034/APJCP.2017.18.5.1383
VANCOUVER
Erturk, K., Tas, F., Serilmez, M., Bilgin, E., Yasasever, V. Clinical Signifıcance of Serum Ykl-40 (Chitinase-3-Like-1Protein) as a Biomarker in Melanoma: an Analysis of 112 Turkish Patients. Asian Pacific Journal of Cancer Prevention, 2017; 18(5): 1383-1387. doi: 10.22034/APJCP.2017.18.5.1383
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