Decreased Mean Platelet Volume is Associated with Cervical Cancer Development

Document Type: Research Articles

Authors

1 Department of Gynaecology and Obstetrics, First Affiliated Hospital of Chinese PLA General Hospital,Harbin Medical University Cancer Hospital, Heilongjiang, 150081, China.

2 Department of Internal Medicine,Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150081, China.

3 Department of Geriatrics, the Second Affiliated Hospital, Harbin Medical University Cancer Hospital, Heilongjiang, 150081, China.

4 Department of Medical Imaging, the Second Affiliated Hospital, Harbin Medical University Cancer Hospital, Heilongjiang, 150081, China.

5 Department of Surgery, James H. Quillen College of Medicine, East Tennessee State University, United States.

6 Division of Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, United States.

Abstract

 
Background: Cervical cancer is the most common gynecological malignant disorder worldwide. Activated platelets play a key role in cancer development and progression. Mean platelet volume (MPV) is an early indicator of platelet activation. The aim of the present study was to evaluate MPV levels in patients with cervical cancer. Materials and methods: A total of 181 patients with cervical cancer and 181 controls between January 2015 and June 2015 were included in the study. Patient characteristics and hematologic test data at initial diagnosis were collected and odds ratios (ORs) and 95% confidence intervals (CIs) for risk of cervical cancer were calculated using multivariate logistic regression analyses across MPV quartiles. Results: MPV levels were decreased in patients with cervical cancer compared with control subjects. A significant correlation between MPV and FIGO stage was found. Moreover, after adjusting for other risk factors, the ORs (95%CIs) for cervical cancer according to MPV quartiles were 4.450 (1.975-10.026), 2.505 (1.206-5.202), 0.573 (0.261-1.259), and 1.000, respectively. Conclusions: MPV was found to be independently associated with the presence of cervical cancer. Our results suggest that MPV could be potential diagnostic screening tool.

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