Salivary MMP-1, MMP-2, MMP-3 and MMP-13 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma

Document Type : Research Articles


1 Oral and Dental Disease Research Center, Department of Oral Medicine,Zahedan University of Medical Science, Zahedan, Iran.

2 Clinical Immunolgy Research Center, Department of ImmunolgyZahedan University of Medical Science, Zahedan, Iran.

3 Dentist, Zahedan University of Medical Science, Zahedan, Iran.


The aim of present study was to evaluate salivary matrix metalloproteinase-1 (MMP-1) , MMP-2, MMP-3 and MMP-13 levels in patients with oral lichen planus (OLP) and squamous cell carcinomas (SCC) as well as in healthy controls. Thirty cases of OLP (bilateral lesions, papular and reticular lesions, and Wickham lines) clinically and histopathologically (group A), 30 with oral SCCs (group B), and 30 with no history of oral cancer, other lesions or lichen planus (group C) were enrolled at the Department of Oral Medicine School of Dentistry, Zahedan, Iran. Unstimulated whole saliva was collected and laboratory measurement of salivary concentration of MMP-1, MMP-2, MMP-3 and MMP-13 was conducted by immuno-sorbent enzyme-linked methods. Data analysis was performed with Kruskal-Wallis and Mann-Whitney tests and Pearson’s correlation coefficients. In the present study, MMP-2 and MMP-13 levels were higher in oral SCC patients than in OLP cases  and healthy individuals. More research is required to assess MMP links with tumor invasion.


Main Subjects

Volume 18, Issue 7
July 2017
Pages 1947-1951
  • Receive Date: 01 May 2017
  • Revise Date: 16 May 2017
  • Accept Date: 17 July 2017
  • First Publish Date: 17 July 2017