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Asian Pacific Journal of Cancer Prevention
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Das, L., Pitty, R., Asokan, K., C.L, K., M.S, A., Ramanathan, A. (2017). Analysis of ARID2 Gene Mutation in Oral Squamous Cell Carcinoma. Asian Pacific Journal of Cancer Prevention, 18(10), 2679-2681. doi: 10.22034/APJCP.2017.18.10.2679
Lakshmi Prabha Das; Raghuram Hari Pitty; Kannan Asokan; Krithika C.L; Anandi M.S; Arvind Ramanathan. "Analysis of ARID2 Gene Mutation in Oral Squamous Cell Carcinoma". Asian Pacific Journal of Cancer Prevention, 18, 10, 2017, 2679-2681. doi: 10.22034/APJCP.2017.18.10.2679
Das, L., Pitty, R., Asokan, K., C.L, K., M.S, A., Ramanathan, A. (2017). 'Analysis of ARID2 Gene Mutation in Oral Squamous Cell Carcinoma', Asian Pacific Journal of Cancer Prevention, 18(10), pp. 2679-2681. doi: 10.22034/APJCP.2017.18.10.2679
Das, L., Pitty, R., Asokan, K., C.L, K., M.S, A., Ramanathan, A. Analysis of ARID2 Gene Mutation in Oral Squamous Cell Carcinoma. Asian Pacific Journal of Cancer Prevention, 2017; 18(10): 2679-2681. doi: 10.22034/APJCP.2017.18.10.2679

Analysis of ARID2 Gene Mutation in Oral Squamous Cell Carcinoma

Article 13, Volume 18, Issue 10, October 2017, Page 2679-2681  XML PDF (309 K)
Document Type: Research Articles
DOI: 10.22034/APJCP.2017.18.10.2679
Authors
Lakshmi Prabha Das 1; Raghuram Hari Pitty1; Kannan Asokan1; Krithika C.L1; Anandi M.S1; Arvind Ramanathan2
1Department of Oral Medicine and Radiology, SRM Dental College, Ramapuram, Chennai, India.
2Enable Biolabs, Madurai Meenakshipuram Extension, Urapakkam, Chennai, India.
Receive Date: 22 March 2017,  Revise Date: 09 September 2017,  Accept Date: 04 October 2017 
Abstract
 
Background: The ARID2 gene, encoding a sub unit of the chromatin remodelling complex, has a possible tumour suppressor function and has been found to be frequently mutated in various tumours, including gingivo buccal oral squamous cell carcinomas. The present study was designed to analyse the presence of ARID2 gene mutations in the distinct genetic South Indian (Dravidian) population. Materials and Methods: Genomic DNA from thirty biopsy tissue samples of histopathologically confirmed cases of oral squamous cell carcinoma (OSCC) were subjected to PCR amplification with intronic primers encompassing exons 19 and 20 of ARID2. Subsequently, the PCR amplicons were purified and subjected to Sanger sequencing using forward primers for analysis of mutational status. Results: Our study yielded a 6% occurrence of mutations in the ARID2 gene among the thirty OSCC samples. Two samples showed a C(5174)A nonsense mutation whereby the "C" nucleotide was substituted with an "A" nucleotide at position 5174, resulting in the conversion of serine amino acid at codon 1725 to a premature STOP codon. Conclusion: Identification of ARID2 gene mutations in OSCCs in this distinct ethnic population reaffirms that aberrations in the chromatin remodelling complex could indeed also contribute to tumorigenesis, thus providing new insights for future research.
Keywords
oral squamous cell carcinoma; ARID2; chromatin remodelling complex; pBAF; mutation
Main Subjects
Cancer biology
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