Ecballium Elaterium for Gastrointestinal Cancer

Document Type : Correspondence and Letter to Editor

Author

Department of Internal Medicine, Naval Hospital of Crete, Chania, Greece.

Abstract

Dear Editor
I read with great interest the article by Jafargholizadeh et al., (2016) for the possible cytotoxic effects of Ecballium elaterium (L.) A. Richard fruit on gastric cancer cells due to its cucurbitacins. Although this toxic
herb has been known since antiquity and was mentioned by ancient writers (as Hippocrates, Theophrastus Pliny,
Dioscorides, Avicenna and others), Hippocrates was the first who suggested the administration of Ecballium
elaterium for the management of gastrointestinal cancer. Particularly, in the Book of Εpidemics II, Hippocrates
of Kos (c. 460 - c. 370 BC) wrote the following: “Ἀπό γαστρός ταραχῆς ἤ ἀπό βηχός καρκίνου γινομένου, τό
στόμα πικραίνεται∙ διδόναι δέ πίνειν ἐλατήριον δίς ἤ τρίς, ἤν μή ψιλός ᾖ” (If you develop cancer after a digestive
disorder or a cough, your mouth becomes bitter. The patient is given elaterium two or three times, unless the
patient is thin) (6,22). The administration of elaterium in this text was probably related to its laxative properties. It
is worth mentioning that the name Ecballium elaterium originates from the Greek words “ἐκβάλλω” (ekvállo)
which means discharge and “ἐλατήριον” (elatírion) which means spring, because of a specific characteristic of the
seeds of the plant, which are ejected like springs, even by the lightest touch of the surface of the fruit, when it is ripe.

Keywords

Main Subjects

Asian Pacific Journal of Cancer Prevention
Volume 19, Issue 3
March 2018
Pages 583-583

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History

  • Receive Date: 12 May 2017
  • Revise Date: 12 February 2018
  • Accept Date: 03 February 2018

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