Association of BRCA1 Promoter Methylation with Breast Cancer in Asia: A Meta- Analysis

Document Type: Systematic Review and Meta-analysis

Authors

1 Doctoral Program, Faculty of Medicine, Universitas Gadjah Mada, Indonesia.

2 Surgical Oncology Divison, Faculty of Medicine Universitas Andalas/ Dr. M Djamil General Hospital Padang, West Sumatera Province, Indonesia.

3 Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta Province, Indonesia.

Abstract

Objective: The aim of this study was to determine the degree of association of BRCA1 promoter methylation with
breast cancer in Asia. Methods: The study sample for the present meta-analysis was provided by published research
articles on associations of BRCA1 promoter methylation with breast cancer in Asia accessed through databases on
PubMed, ProQuest and EBSCO published between 1997 and November 2017. Pooled odds ratios (OR) were calculated
with fixed and random-effect models. Data were processed using Review Manager 5.3 (RevMan 5.3). Results: Of
a total of 475 articles, 11 studies were included in our systematic review with meta-analysis of relevant data. The
results showed a highly significant association between BRCA1 promoter methylation with breast cancer in Asia
(OR = 8.78 [95% CI 4.15-18.56, p < 0.00001]). Conclusion: This analysis confirmed association between BRCA1
promoter methylation and breast cancer in Asia. BRCA1 promoter assessment might be a predictive or diagnostic aid
for breast cancer prediction.

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