Document Type: Research Articles
Pharmacology and Therapy Department, Faculty of Medicine, University Gadjah Mada, Yogyakarta, Indonesia.
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University Muhammadiyah, Purwokerto, Indonesia.
Faculty of Health Sciences, University Indonesia, Indonesia.
Department of Surgery, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Introduction: The breast cancer related incidence and mortality rate in Indonesia are included in the top 10 and
top 5 highest in the world. A country-specific Health Related Quality of Life measurement tool is required to help
clinician observe and improve the management of the disease. Methods: We developed the questionnaire, namely
Indonesian Breast Cancer Health Related Quality of Life (INA-BCHRQoL) by incorporating not only the generic
variables such as physical, psychological, and social; but also spiritual variable which is suitable for Indonesian
population. The questionnaire was validated to the same population using the value of corrected item-total correlation
and the value of Cronbach Alpha. Results: Fourty three questions were considerably valid and reliable on evaluating
the HRQoL of early state of breast cancer patients in Indonesia as the value of Cronbach Alpha for physical, cognitive,
social and spiritual domain were higher than 0.8 and the corrected item-total correlation were also higher than 0.3.
Each domain of the questionnaire was not influenced by the treatment options. Twenty four early stage breast cancer
(10 FAC based chemotherapy and 14 Taxan based chemotherapy) were enrolled in the main study and the score of
HRQOL obtained from INA-BCHRQoL were considerably high. Conclussion: The INA-BCHRQoL questionnaire
can be implemented as a valid and reliable tool to assess quality of life in early stage breast cancer patients in Indonesia.