Document Type: Research Articles
Department of Radiation Oncology, Shohada-e-Tajrish Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cancer Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran.
Background: Axillary lymph node metastasis is the most important predictive factor for recurrence risk and
survival in patients with invasive breast carcinoma. The aim of this study was to determine factors associated with
metastatic involvement of axillary lymph nodes in Iranian women with early breast cancer. Methods: This article reports
a retrospective study of 774 patients with T1-T2 breast cancer who underwent resection of the primary tumor and axillary
staging by SLNB and/or ALND between 2005 and 2015 at our institution. Results: Of the 774 patients included in this
study, 35.5% (275 cases) had axillary lymph node involvement at the time of diagnosis. Factors associated with nodal
involvement in univariate analyses were tumor size, lymphovascular invasion (LVI), tumor grade, ER/PR status and
HER2 expression. All factors identified with univariate analyses were entered into a multivariate logistic regression
model and tumor size (OR= 3.01, CI 2.01–4.49, P <0.001), ER/PR positivity (OR = 1.74, CI 1.1.16–2.62, P = 0.007)
and presence of LVI (OR = 3.3.8, CI 2.31–4.95, P <0.001) remained as independent predictors of axillary lymph node
involvement .Conclusions: In conclusion, the results of this study suggests that positive hormonal receptor status, LVI
and tumor size are predictive factors for ALNM in Iranian women with early breast cancer.