Document Type: Research Articles
Razi Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Immunology and Biology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Objective: Interleukin-6 (IL-6) is an inflammatory cytokine shown to be a strong factor for growth, proliferation and
metastasis with many malignancies. The promoter single nucleotide polymorphism (SNPs) -174G>C (rs1800795) can
alter the transcriptional pattern of this gene. The present study was aimed at assessing effects of the IL-6 (rs1800795)
SNP on risk of benign prostate hyperplasia (BPH) and prostatic adenocarcinoma (PCa). Methods: The project was
performed on 112 men with PCa, 118 with BPH and 250 healthy controls. After DNA extraction, genotyping of IL-6
(rs1800795) was performed using PCR TaqMan Allelic Discrimination (ABI MGB). Results: The G allele frequency
for rs1800795 of the IL-6 gene was 74.1%, 68.6% and 67% in PCa patients, BPH patients and healthy men, respectively.
PCa and control groups showed significant differences (P =0.030, OR = 1.73, 95% CI: 1.05-2.21). The GG genotype
was more frequent in the PCa group, whereas the GC genotype was more common in the BPH in comparison to other
groups. Conclusion: The current study identified IL-6 -174G>C (rs1800795) as a significant predictor of susceptibility
for prostate cancer and bone metastasis in a northwest Iranian population.