An Interleukin-6 Single Nucleotide Polymorphism and Susceptibility to Prostate Adenocarcinoma and Bone Metastasis in an Iranian Population

Document Type: Research Articles

Authors

1 Razi Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

2 Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.

3 Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

4 Department of Immunology and Biology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

5 Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

6 Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Objective: Interleukin-6 (IL-6) is an inflammatory cytokine shown to be a strong factor for growth, proliferation and
metastasis with many malignancies. The promoter single nucleotide polymorphism (SNPs) -174G>C (rs1800795) can
alter the transcriptional pattern of this gene. The present study was aimed at assessing effects of the IL-6 (rs1800795)
SNP on risk of benign prostate hyperplasia (BPH) and prostatic adenocarcinoma (PCa). Methods: The project was
performed on 112 men with PCa, 118 with BPH and 250 healthy controls. After DNA extraction, genotyping of IL-6
(rs1800795) was performed using PCR TaqMan Allelic Discrimination (ABI MGB). Results: The G allele frequency
for rs1800795 of the IL-6 gene was 74.1%, 68.6% and 67% in PCa patients, BPH patients and healthy men, respectively.
PCa and control groups showed significant differences (P =0.030, OR = 1.73, 95% CI: 1.05-2.21). The GG genotype
was more frequent in the PCa group, whereas the GC genotype was more common in the BPH in comparison to other
groups. Conclusion: The current study identified IL-6 -174G>C (rs1800795) as a significant predictor of susceptibility
for prostate cancer and bone metastasis in a northwest Iranian population.

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