Document Type: Research Articles
Department of Dental Clinic, Division of Oral Pathology, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceara, Fortaleza, Brazil.
Department of Oral Pathology, Fortaleza University, Fortaleza, Brazil.
Department of Pharmacology, School of Dentistry, Federal University of Ceara, Campus Sobral, Sobral, Brazil.
Departament of Morphology, School of Medicine, Federal University of Ceara, Brazil.
Objectives: To evaluate immunohistochemically the expression of GLUT-3 and GLUT-4 in oral epithelial dysplasia
(OED) and the oral squamous cell carcinoma (OSCC) and assess possible involvement in the malignant transformation of
oral lesions. Methods: Tissue samples of 15 cases of OSCC and 15 of OED were subjected to immunohistochemistry
with anti-GLUT-3 and anti-GLUT-4 antibodies. Five fields of each case were analyzed, to provide percentages of
positive cells at 400X magnification. Result: GLUT-3 and GLUT-4 were positive in 100% of the analyzed samples,
the percentage immunolabeling for GLUT-3 ranging from 19% to 73% in the OED group and 10% to 89% in the OSCC
group. Positive immunolabeling for GLUT-4 ranged from 15.2% to 79.9% in the OSCC group and 27.1% to 92.6% in
the OED group. Statistical analysis with the Mann-Whitney test revealed that there was a higher expression of GLUT-4 in
the OED group than in the OSCC group (p=0.04) without any significant difference in the GLUT-3 expression (p=0.852).
Conclusion: GLUT-4 expression may indicate some role in oncogenic mechanisms which can determine a malignant
phenotype. Thus, it is suggested that further studies on the role of GLUT-3 in oral carcinogenesis be conducted.