Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a major toxicity that requires treatment modification or cessation and worsens patients’ quality of life. Its incidence is 30–40%. Occurrence and severity depend on treatment- and patient-related factors. The symptoms are self-limiting with recovery rate about 50%. Methods: This retrospective analysis took place in our chemotherapy unit. We included patients treated between January 2014 and December 2015. Results: 250 patients were eligible. 53 received paclitaxel, 78 received docetaxel, 64 received cisplatin and 55 received oxaliplatin. Mean age was 50.11 years. Frequency of CIPN was 46.8% (Grade I 70.9%, GII 24.7%, GIII 4.4%). It was 74% with oxaliplatin, 73.5% with paclitaxel, 35.9% with cisplatin and 17.9% with docetaxel. After median of 6 months 24% of patients recovered completely. No significant correlation between occurrence of CIPN and age (p = 0.781), while was significant with cisplatin (p = 0.043). Diabetic patients had higher incidence (p = 0.007). With cisplatin, median cumulative dose of 450 mg/m2 and ≥ 6 cycles had higher incidence of CIPN (p 0.006 and 0.010; respectively). With oxaliplatin, none was correlated with CIPN frequence. With paclitaxel, CIPN was more frequent if ≥ 4 cycles were received (p = 0.005). With docetaxel, > 4 cycles or cumulative dose ≥ 360 mg/m2 had higher occurrence of GII CIPN (p < 0.001 for both). Conclusion: CIPN is common problem that affects patients’ quality of life and leads to treatment interruption. There are many factors affecting its incidence and severity.
Gaballah, A., Shafik, A., Elhusseiny, K., Ashraf, M. (2018). Chemotherapy-Induced Peripheral Neuropathy in Egyptian Patients: Single Institution Retrospective Analysis. Asian Pacific Journal of Cancer Prevention, 19(8), 2223-2227. doi: 10.22034/APJCP.2018.19.8.2223
MLA
Ahmed Gaballah; Amr Shafik; Khaled Elhusseiny; Mai Ashraf. "Chemotherapy-Induced Peripheral Neuropathy in Egyptian Patients: Single Institution Retrospective Analysis". Asian Pacific Journal of Cancer Prevention, 19, 8, 2018, 2223-2227. doi: 10.22034/APJCP.2018.19.8.2223
HARVARD
Gaballah, A., Shafik, A., Elhusseiny, K., Ashraf, M. (2018). 'Chemotherapy-Induced Peripheral Neuropathy in Egyptian Patients: Single Institution Retrospective Analysis', Asian Pacific Journal of Cancer Prevention, 19(8), pp. 2223-2227. doi: 10.22034/APJCP.2018.19.8.2223
VANCOUVER
Gaballah, A., Shafik, A., Elhusseiny, K., Ashraf, M. Chemotherapy-Induced Peripheral Neuropathy in Egyptian Patients: Single Institution Retrospective Analysis. Asian Pacific Journal of Cancer Prevention, 2018; 19(8): 2223-2227. doi: 10.22034/APJCP.2018.19.8.2223
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