Background: Endometrial carcinomas are common gynecologic malignancies worldwide. In Egypt they represent 2.6 %. We evaluated the role of morphometry and MMP-9 immunohistochemical expression to differentiate atypical endometrial hyperplasia from low grade endometrial adenocarcinoma. Methods: 60 cases of endometrial lesions that included 25 cases of complex endometrial hyperplasia with atypia, 25 cases of low grade endometrioid adenocarcinoma, in addition to 10 cases of proliferative endometrium as a control group. Morphometric measurements and D-score were evaluated. MMP9 was performed using streptavidin –biotin immunoperoxidase system. Results: D score was more than 1 in 100% of cases of proliferative endometrium. In atypical hyperplasia 28 % of cases had a D-score more than 1, 44% less than 0 and 28% of cases had a D score between 0 and 1 with uncertain prognosis. All carcinoma cases had D-score less than 0. MMP9 was positive in all cases of the study but differ in its degree of expression; proliferative endometrium with low expression. Atypical hyperplasia divided as 52% low expression and 48% high expression. Most of the Endometrial adenocarcinoma cases (92%) showed high expression. There was significant difference in expression of MMP9 in atypical endometrial hyperplasia and endometrial adenocarcinoma (p> 0.001). Conclusion: The relation between MMP9 expression and D-score value in cases of atypical endometrial hyperplasia was highly significant P>0.001Thus, incorporating both MMP9 immunoexpression and D-score value would increase the accuracy of diagnosis of atypical endometrial hyperplasia and low grade endometrial adenocarcinoma.
Assaf, M. I., Abd El-Aal, W., Mohamed, S. S., Yassen, N. N., & Mohamed, E. A. (2018). Role of Morphometry and Matrix Metalloproteinase-9 Expression in Differentiating between Atypical Endometrial Hyperplasia and Low Grade Endometrial Adenocarcinoma. Asian Pacific Journal of Cancer Prevention, 19(8), 2291-2297. doi: 10.22034/APJCP.2018.19.8.2291
MLA
Magda I Assaf; Wafaa Abd El-Aal; Samah S Mohamed; Noha N Yassen; Eman A Mohamed. "Role of Morphometry and Matrix Metalloproteinase-9 Expression in Differentiating between Atypical Endometrial Hyperplasia and Low Grade Endometrial Adenocarcinoma". Asian Pacific Journal of Cancer Prevention, 19, 8, 2018, 2291-2297. doi: 10.22034/APJCP.2018.19.8.2291
HARVARD
Assaf, M. I., Abd El-Aal, W., Mohamed, S. S., Yassen, N. N., Mohamed, E. A. (2018). 'Role of Morphometry and Matrix Metalloproteinase-9 Expression in Differentiating between Atypical Endometrial Hyperplasia and Low Grade Endometrial Adenocarcinoma', Asian Pacific Journal of Cancer Prevention, 19(8), pp. 2291-2297. doi: 10.22034/APJCP.2018.19.8.2291
VANCOUVER
Assaf, M. I., Abd El-Aal, W., Mohamed, S. S., Yassen, N. N., Mohamed, E. A. Role of Morphometry and Matrix Metalloproteinase-9 Expression in Differentiating between Atypical Endometrial Hyperplasia and Low Grade Endometrial Adenocarcinoma. Asian Pacific Journal of Cancer Prevention, 2018; 19(8): 2291-2297. doi: 10.22034/APJCP.2018.19.8.2291
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