Could Anthropometric and Lipid Parameters Reflect Susceptibility to Breast Cancer? Comparison of Newly Diagnosed Breast Cancer and Apparently Healthy Women

Document Type: Research Articles

Authors

1 Department of Biochemistry, Faculty of Medical Sciences, University of Sri Jayewardenepura,Gangodawila, Nugegoda, Sri Lanka.

2 Department of Biochemistry, Faculty of Medicine, South Asian Institute of Technology and Medicine, Sri Lanka.

3 Department of Pathology, Faculty of Medical Sciences, University of Sri Jayewardenepura,Gangodawila, Nugegoda, Sri Lanka.

Abstract

Objectives: To determine and compare the serum lipid profiles and anthropometric parameters of newly diagnosed
BC patients and healthy women. Methods: Serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C),
low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), triglyceride (TG)
and TC: HDL-C were measured in consent obtained newly diagnosed BC patients (n=155) and age matched apparently
healthy females (n=75). Weight (W), height (H), waist circumference (WC), hip circumference (HC) and mid upper arm
circumference (MUC) of each women were recorded. Cut off values for each parameter was found by receiver operative
characteristic (ROC) curves and risk associated with was calculated using SPSS version 16. Results: Majority (67%)
of BC women were postmenopausal. The mean TC, HDL-C, LDL-C, VLDL-C, TC: HDL-C, TG concentrations of
BC patients who were not on cholesterol lowering drugs (n= 126) were 234 mg/dL (±51), 43 mg/dL (±10), 164 mg/dL
(±44), 27 mg/dL (±14), 5.7(±1.7) and 135 mg/dL (±69) respectively. TC, LDL-C and TC: HDL-C of BC patients were
significantly elevated when compared with healthy females. Significant difference in serum lipid profile parameters was
not observed (p> 0.05) according to the menopausal status of BC and healthy women. One third (30.3%) of BC patients
were overweight and 45% were obese. Majority had elevated WC (72%), W: H ratios (89%) and MUC (89%). BMI,
W: H and MUC of BC women were significantly higher (p<0.05) when compared with healthy females. Conclusions:
The lipid parameters TC, LDL-C and TC: HDL-C above 203 mg/dL, 139 mg/dL and 3.9 respectively were risk factors.
Among anthropometric measures, BMI>25 kg/m2 showed the highest risk while elevated W:H and MUC were also
significant risk factors among the study group.

Keywords

Main Subjects