The Effect of Gluten Free Diet on Components of Metabolic Syndrome: A Randomized Clinical Trial

Document Type: Research Articles

Authors

1 Department of Clinical Nutrition and Dietetics,, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Department of Basic Medical Sciences, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Cellular and Molecular Endocrine Research Center, Research Institute of Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

4 Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Background: This study aimed to assess the effects of Gluten free diet (GFD) on components of metabolic syndrome
(MES). Materials and Methods: In this randomized clinical trial, 50 subjects diagnosed with MES were randomly
divided into two groups (n=25). The first group received a GFD and the second group continued their regular diet.
Biochemical markers of MES and blood pressure were measured before and after 8-week intervention. Results: Forty
five subjects completed the study. A post-hoc comparison of the groups showed no effects of the GFD and control
diet on LDL cholesterol, total cholesterol, fasting insulin, HOMA-IR, systolic and diastolic blood pressure levels. The
GFD reduced fasting blood glucose, waist circumference (WC) and serum triglyceride concentration significantly
compared with the control diet (p<0.05). Conclusion: Short-term GFD reduced WC and improved glycemic control
and Triglyceride level in subjects with the metabolic syndrome.

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