Determining Overall Survival and Risk Factors in Esophageal Cancer Using Censored Quantile Regression

Document Type: Research Articles

Authors

1 Modeling in Health Research Center, Department of Epidemiology and Biostatistics, School of Public Health, Shahrekord University of Medical Sciences, Shahrekord, Iran.

2 Department of Epidemiology and Biostatistics, School of public Health, Tehran University of Medical Sciences, Tehran, Iran.

3 School of Public Health, University of Alberta, Edmonton, Alberta, Canada.

4 Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Abstract

Background: Esophageal cancer is one of the leading causes of death worldwide. The global increasing rate of this
type of cancer requires more attention. The purpose of this study was to determine the overall survival probability of
esophageal cancer after diagnosis and to assess the potential risk factors in a population of Iranian patients. Materials
and Methods: This retrospective cohort study was conducted on 127 cases with esophageal cancer in the Azarbaijan
province, East of Iran. Participants in the study were diagnosed during 2009-2010 and were followed up for 5 years. The
event was considered death due to esophageal cancer and those who survived until the end of the study were assumed as
right censored. Censored quntile regression was fitted to find the overall survival of the patients using adjusted effects of
variables and was compared with Cox regression model. Results: Patients’ mean and median survival time were 16.99
and 10.06 months respectively and 89% off cases died by the end of the study. The 1, 3, 6, 12 and 36-month survival
probabilities were 0.95, 0.76, 0.60, 0.43, and 0.18. The median survival time for females and males without surgery
were 21.79 and 14.76 month respectively. The accuracy of predictions were 0.99 and 0.74 for the censored quantile
regression and Cox, respectively. Conclusion: We concluded that being male, not having surgery, longer wait time
between having symptoms and being diagnosed, low socioeconomic status and old age to be significant risk factors in
reducing the probability of survival from esophageal cancer.

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