Association between rs1862513 and rs3745367 Genetic Polymorphisms of Resistin and Risk of Cancer: A Meta-Analysis

Document Type: Systematic Review and Meta-analysis

Authors

1 Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

2 Student Research Committee, Zahedan University of Medical Sciences, Zahedan, Iran.

3 Department of Clinical Biochemistry, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran.

4 Children Hospital Research Institute of Manitoba, Biology of Breathing Theme, University of Manitoba, Winnipeg, Canada.

5 Health policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.

6 Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Abstract

The present study aimed to assess any associations between resistin gene (RETN) polymorphisms and cancer
susceptibility by conducting a meta-analysis. A comprehensive literature search was performed with PubMed, Web of
Science, Scopus and Google Scholar for relevant studies published before April 2018. For the rs1862513 polymorphism,
data from 9 studies covering 1,951 cancer patients and 2,295 healthy controls were included in this meta-analysis. Pooled
odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Our meta-analysis revealed that this RETN
polymorphism significantly increased the risk of cancer in codominant (OR=1.23, 95% CI= 1.01-1.50, p=0.04, CG vs CC;
and OR=1.25, 95% CI= 1.03-1.53, p=0.03, GG vs CC), dominant (OR=1.19, 95% CI= 1.05-1.35, p=0.006, CG+GG vs CC),  CI= 1.00-1.30, p=0.04, G vs C) inheritance genetic models. Stratification analysis by cancer
type revealed that the rs1862513 variant significantly increased the risk of colorectal and breast cancer, and that cancer
overall in Caucasians (OR=1.22, 95% CI= 1.04-1.43, p=0.02, CG+GG vs CC; OR=1.18, 95% CI= 1.04-1.34, p=0.01,
G vs C). The data revealed no correlation between the rs3745367 polymorphism and cancer risk. Further well-designed
studies with larger sample sizes and different ethnicities are warranted to validate the present findings.

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