The Tendency of Having MSH2 and MSH6 Microsatellite Instability among Clinicopathological Features in Patients with Colorectal Cancer

Document Type : Research Articles

Authors

1 Department of Histology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

2 Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

3 Department of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Abstract

Objective: This study aimed to identify micro-satellite instability (MSI) based on the expression of MMRp (MSH2
and MSH6) and to evaluate the association of MSI and with clinicopathological features in patients with colorectal
cancer (CRC). Methods: MMRp expression in 80 tissue samples from patients with adenocarcinoma CRC were
evaluated by using anti-MSH2 and -MSH6 antibodies. Loss of MSH2 and/or MSH6 expression was stated as MSI.
The association between MSI status and clinicopathological features were analyzed by using binary logistic regression
(p<0.05). Results: The frequency of MSI in patients with CRC varied, corresponding to 8.3% (6/72) MSH2 MSI,
36.1% (26/72) MSH6 MSI and 6.9% (5/72) MSH2-MSH6 MSI. Male patients (OR=1.98), with tumor located in colon
(OR=1.47) and late stage tumor (OR=1.48) have a tendency of having MSH2 MSI. Male patients (OR=1.4), with tumor
located in colon (OR=2.53) and poor tumor differentiation (OR=3.02) have a tendency to encounter MSH6 MSI. Male
patients (OR=4.93) with late stage tumor (OR=1.69) have a tendency of having MSH2-MSH6 MSI. Conclusion:
Patients more likely to have MSH2 MSI are males, and/or having tumor located in colon, and /or having late stage
tumor. Patients more likely to have MSH6 MSI are males, and/or having tumor located in colon, and/or having tumor
with poor differentiation. Patients who have greater tendency to have MSH2 and MSH6 MSI are males, and/or having
late stage tumor.

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References

 
Asian Pacific Journal of Cancer Prevention
Volume 19, Issue 11
November 2018
Pages 3147-3152

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History

  • Receive Date: 19 February 2018
  • Revise Date: 12 August 2018
  • Accept Date: 02 October 2018

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