Targeting Inflammation in Ovarian Cancer Through Natural Antioxidants, Potential Therapeutic and Preventive Implications

Document Type: Editorials

Authors

1 Department of Medical Oncology (Lab), Dr BR Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Delhi, India.

2 Department of Preventive Oncology, Dr BR Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Delhi, India.

3 Director General, Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Government of India, Delhi, India.

4 Secretary, Ministry of AYUSH, Government of India, Delhi, India.

5 Professor and Chief, Dr BR Ambedkar Institute Rotary Cancer Hospital & Head, National Cancer Institute - India, All India Institute of Medical Sciences, Delhi, India.

Abstract

There is extensive experimental data to support
the hypothesis that Reactive oxygen species (ROS)
accumulation is one of the major underlying mechanism
for carcinogenesis. Many forms of cancer are associated
with excessive accumulation of ROS including ovarian
cancer. It is now well understood that ROS production
should be scavenged by antioxidant defence mechanism/
DNA damage response of the human body to maintain
natural homeostasis (Kruk and Aboul-Enein, 2017).
Dysregulation of this balance leads to many inflammatory
diseases including the high risk of developing cancer. High
ROS concentration is associated with accumulation of
mutations which over the years leads to development of
cancer. Metabolic pathways including aerobic oxidation
in mitochondria respiratory are the major source of ROS
which in turn effect different signalling pathways (Kruk
and Aboul-Enein, 2017).