Document Type: Research Articles
Section Medical Oncology, Oncology Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Department Radiation Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Department of Breast Surgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Introduction: Pregnancy Associated Breast cancer (PABC) is associated with poor prognosis and a decreased overall
survival. A retrospective review was conducted to review the experience and outcome in a tertiary care hospital, and to
compare those seen in a matched group for year of diagnosis. Materials and Methods: This is a retrospective review
of a prospectively collected breast cancer registry. The study was conducted in a tertiary care hospital in Riyadh, Saudi
Arabia from January to Decamber 2014 . Female patients with PABC were identified and matched with similar cohort
of non-pregnant breast cancer patients that were diagnosed between 2001-2010. Clinical data including age, tumor
biology, clinical stage, follow up and outcomes (disease free survival, DFS) were analyzed and compared between the
two groups using SAS 9.3 and R-2.14.1 Results: A total of 110 patients in Group 1 and 114 patients in Group II were
analyzed. In both groups, the patient age ranged was between 20 to 45 years; the median follow up was 34 months in
PABC and 54 months in non-pregnant cohort. PABC were statistically more likely to be triple negative (p value-0.05) and
diagnosed at advanced stage (stage 3 and 4) (p value-0.02). There was no difference in the occurrence of Her-2 positive
disease. In pregnant patients there was a 5-year survival rate of 65% compared to non-pregnant cohort of 82% with p
value of 0.002 and DFS was also 47.5% versus 65.4% with a p value .002 which is statistically significant. Conclusion:
Pregnancy associated breast cancer (PABC) is diagnosed at a more advanced stage and tends to be triple negative and
they are associated with a worse DFS and overall survival. Early detection during pregnancy may improve outcome.