Incidence and Risk Factors for Bone Metastasis in Non-Small Cell Lung Cancer

Document Type: Research Articles

Authors

National Cancer Institute and Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.

Abstract

Background: Bone is a frequent site of metastasis from various primary cancers including with Non-Small Cell
Lung Cancer. The aim of this study was to investigate the incidence and risk factors for Bone Metastasis in patients with
Non-Small Cell Lung Cancer. Methodology: A cohort study was carried out in patients diagnosed with Non-Small Cell
Lung Cancer between 2006 and 2014 in a single cancer centre. A descriptive analysis of the population was compiled
based on mean ± standard deviation (SD) for continuous variables and percentage (%) for categorical variables.
Univariate and multivariate Cox proportional hazards regression analyses were carried out to quantify the relationship
between independent variables and the outcome variable (Bone Metastasis). Results: During the study period 1025
patients were diagnosed with Non-Small Cell Lung Cancer. Bone Metastasis was detected in 136 patients (13.2%)
with a mean interval between Non-Small Cell Lung Cancer diagnosis and Bone Metastasis of 8.07 months (95% CI:
7.68 8.45). Multivariate analysis revealed that younger age (HR 0.97; 95%CI, 0.95–0.99; p=0.002), adenocarcinoma
(HR 1.51; 95%CI, 1.06–2.15; p=0.021) and treatment with chemotherapy, radiotherapy or chemotherapy combined
with radiotherapy (HR 3.73; 95%CI, 2.30–6.05; p<0.001) were associated with the occurrence of Bone Metastasis.
Conclusion: The incidence of Bone Metastasis was 13.2%. Younger age, histological subtype adenocarcinoma and
treatment with chemotherapy, radiotherapy or chemotherapy combined with radiotherapy are independent risk factors
for Bone Metastasis.

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