Background: Bone is a frequent site of metastasis from various primary cancers including with Non-Small Cell Lung Cancer. The aim of this study was to investigate the incidence and risk factors for Bone Metastasis in patients with Non-Small Cell Lung Cancer. Methodology: A cohort study was carried out in patients diagnosed with Non-Small Cell Lung Cancer between 2006 and 2014 in a single cancer centre. A descriptive analysis of the population was compiled based on mean ± standard deviation (SD) for continuous variables and percentage (%) for categorical variables. Univariate and multivariate Cox proportional hazards regression analyses were carried out to quantify the relationship between independent variables and the outcome variable (Bone Metastasis). Results: During the study period 1025 patients were diagnosed with Non-Small Cell Lung Cancer. Bone Metastasis was detected in 136 patients (13.2%) with a mean interval between Non-Small Cell Lung Cancer diagnosis and Bone Metastasis of 8.07 months (95% CI: 7.68 8.45). Multivariate analysis revealed that younger age (HR 0.97; 95%CI, 0.95–0.99; p=0.002), adenocarcinoma (HR 1.51; 95%CI, 1.06–2.15; p=0.021) and treatment with chemotherapy, radiotherapy or chemotherapy combined with radiotherapy (HR 3.73; 95%CI, 2.30–6.05; p<0.001) were associated with the occurrence of Bone Metastasis. Conclusion: The incidence of Bone Metastasis was 13.2%. Younger age, histological subtype adenocarcinoma and treatment with chemotherapy, radiotherapy or chemotherapy combined with radiotherapy are independent risk factors for Bone Metastasis.
da Silva, G., Bergmann, A., Thuler, L. (2019). Incidence and Risk Factors for Bone Metastasis in Non-Small Cell Lung Cancer. Asian Pacific Journal of Cancer Prevention, 20(1), 45-51. doi: 10.31557/APJCP.2019.20.1.45
MLA
Gustavo Telles da Silva; Anke Bergmann; Luiz Claudio Santos Thuler. "Incidence and Risk Factors for Bone Metastasis in Non-Small Cell Lung Cancer". Asian Pacific Journal of Cancer Prevention, 20, 1, 2019, 45-51. doi: 10.31557/APJCP.2019.20.1.45
HARVARD
da Silva, G., Bergmann, A., Thuler, L. (2019). 'Incidence and Risk Factors for Bone Metastasis in Non-Small Cell Lung Cancer', Asian Pacific Journal of Cancer Prevention, 20(1), pp. 45-51. doi: 10.31557/APJCP.2019.20.1.45
VANCOUVER
da Silva, G., Bergmann, A., Thuler, L. Incidence and Risk Factors for Bone Metastasis in Non-Small Cell Lung Cancer. Asian Pacific Journal of Cancer Prevention, 2019; 20(1): 45-51. doi: 10.31557/APJCP.2019.20.1.45
)