Document Type: Research Articles
Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran.
Department of Radiology, Medical Imaging Center, Tehran University of Medical Sciences, Tehran, Iran.
Quantitative MR Imaging and Spectroscopy Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Gynecology Oncology, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Background: To evaluate the utility of the pharmacokinetic modeling derived from dynamic contrast-enhanced
magnetic resonance imaging (DCE-MRI) in differentiating benign from malignant adnexal masses. Methods: A total of
43 patients with 49 complex adnexal masses (27 benign, 3 borderline, and 19 malignant lesions) underwent preoperative
DCE-MRI examinations on a 3 Tesla MRI. Using extended Tofts’ model, quantitative analysis was performed in the
solid components of all tumors. Three pharmacokinetic parameters were defined as volume transfer coefficient (Ktrans),
the rate constant (Kep), and the plasma volume (Vp). Semi-quantitative analysis was also performed and the values
of relative signal intensity (SI rel) wash-in-rate (WIR), the initial area under the curve (iAUC60), time-to-peak (TTP)
and wash-out-rate (WOR) were calculated. Receiver operating characteristic (ROC) curve analysis was performed to
evaluate diagnostic characteristics of each DCE-MRI parameter in differentiating borderline/malignant tumors from
benign lesions and to provide the optimal cutoff values for these variables. Results: SI rel had the highest diagnostic value
(AUC=0.872; p<0.001; cut-off=121.4 associated with an overall accuracy=79.6%, sensitivity=95.5%, specificity=66.7%,
NPV=94.8% and PPV=70.0%). Ktrans had the second highest AUC=0.836 (p<0.001; cut-off=0.034 associated with an
overall accuracy=79.6%, sensitivity=86.4%, specificity=74.1%, NPV=87.0% and PPV=73.1%). The other factors found
to be acceptable diagnostic parameters for borderline/malignant lesions included WIR (AUC=0.816; p<0.001), iAUC60
(AUC=0.808; p<0.001), Vp (AUC=0.795; p<0.001), SI max (AUC=0.737, p=0.005), SI peak (AUC=0.737; p=0.005)
and Kep (AUC=0.681; p=0.031). Conclusion: Quantitative DCE-MRI is a relevant tool for differentiating benign from
malignant adnexal masses. Among all the DCE parameters, SI rel and Ktrans are the most accurate discriminators.