Alteration of the Risk of Oral Pre-cancer and Cancer in North India Population by CYP1A1 Polymorphism Genotypes and Haplotype

Document Type: Research Articles

Authors

1 Department of Oral Pathology and Microbiology, King George’s Medical University, Lucknow, India.

2 Amity Institute of Biotechnology, Amity University, Lucknow, India.

3 Department of Surgery, SHM Medical College, Saharanpur, U.P.

4 Department of Biochemistry, King George’s Medical University, Lucknow, India.

5 Department of Radiotherapy, King George’s Medical University, Lucknow, India.

Abstract

Background: The aim of this study was to evaluate any association between CYP1A1 (T6235C and C4887A,
A4889G) gene polymorphisms and the risk of oral pre-cancer and cancer. Methods: In the present study, 250 patients
with oral pre-cancer and/or cancer and 250 healthy controls were genotyped for CYP1A1 T6235C, C4887Aand A4889G
polymorphisms by the PCR-RFLP method. Results: None of the CYP1A1 polymorphisms were associated with the risk of
either oral cancer or pre cancer. Nor were any links with clinical parameters of oral cancer found. However, among the
consumers of areca nut/pan masala the TC, CA and AG genotypes respectively for the CYP1A1 T6235C,C4887Aand
A4889G polymorphisms were significantly more frequent in controls compared to cases ( p values for cases vs. controls
of 0.0032, 0.0019 and 0.0009, respectively). Similarly, compared to the haplotype TCA, TAG constituted by CYP1A1
T6235C and C4887A and A4889G was more common in controls (6.88%) than in cases (4.07%). Conclusion: Our
results suggest that genotypes regarding CYP1A1 polymorphisms may modulate the risk of oral cancer and pre-cancer
among the areca nut/pan masala consumers. The haplotype may also exert an influence in our north Indian population.

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