OGG1 rs1052133 Polymorphism and Genetic Susceptibility to Chronic Myelogenous Leukaemia

Document Type: Research Articles

Author

Department of Clinical laboratory Science, College of Applied Medical Science, Imam Abdulrahman, Bin Faisal University, Saudi Arabia.

Abstract

Background: In some cancer cells, the OGG1 gene is somatically mutated and highly populated. This study was
conducted to examine whether OGG1 rs1052133 polymorphism is associated with the genetic background of chronic
myelogenous leukaemia (CML) in Sudan. Methods: A total of 332 CML patients and 70 healthy controls were included
in this study. Overall, the genotypes (P=0.0000) and allele (C vs. G, P=0.0007) differed considerably in the frequencies
of OGG1 rs1052133 polymorphism between CML patients and controls. Our study is the first to evaluate the association
of polymorphism with CML risk with OGG1 rs1052133. Results: A statistically significant association was observed
between the genotype distribution of OGG1 rs1052133 polymorphism and CML (P=0.0000) patients. A similar result
was also observed in the allele distribution (C vs. G, P=0.0007) compared with healthy controls when compared
OGG1 rs1052133 genotypes with CML stages. Results: Genotype and allele frequencies of OGG1 rs1052133 among
CML patients. A statistically significant association was observed between the genotype distribution of the OGG1
rs1052133 polymorphism and CML patients (P=0.0000). A similar result was also observed in the allele distribution
(C vs. G, P=0.0007) compared with healthy controls with stages of CML in OGG1 rs1052133 genotypes. Conclusion:
The results suggest that single nucleotide polymorphism in the gene involved in the restoration of DNA base excision
(OGG1 rs1052133) can play a key role in the risk of appearance of CML. To clarify the role of OGG1 in the genetic
basis of CML, further case control with larger sample sizes and fine-mapping is required.

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