Document Type : Research Articles
Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science, Osaka, Japan.
Department of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
Department of Public Health, Wakayama Medical University School of Medicine, Wakayama, Japan.
Faculty of Nutrition, University of Kochi, Kochi, Japan.
Department of Hygiene and Preventive Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan.
Background: Recently, the number of colorectal cancer (CRC) cases in Japan has been increasing, and is strongly
influenced by alcohol consumption. On the other hand, there are several reports suggesting a relationship between
bowel movement (constipation and diarrhea) and CRC development. Moreover, it is generally known that diarrhea
may occur after drinking. However, the mechanism by which drinking alcohol increases CRC is not fully clarified
yet. We hypothesized that diarrhea after drinking may play an important role in colorectal carcinogenesis. Methods:
We examined the presence of diarrhea after drinking and further evaluated the correlation of diarrhea after drinking
with the incidence of colorectal tumors. To obtain the status of the feces, a self-recorded questionnaire survey was
administered using the dietary-recording method. Blood samples were obtained to analyze the ALDH2 Glu504Lys and
ADH1B His48Arg polymorphisms. Results: The participants were 417 patients who had undergone a total colonoscopy.
The control was selected from 186 patients who underwent a medical checkup at the same hospital during the same
time period. The odds ratio for all subjects was 2.1 (95% CI: 1.18 - 3.80), and that for heavy drinkers was 4.2 (1.48
- 11. 90). Conclusions: The results demonstrated that those who have diarrhea after drinking possess a high risk of
developing colon tumors.