Document Type: Research Articles
Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang,China.
Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
Background: Deep venous thrombosis (DVT) is associated with severe morbidity and mortality in cancer. Platelet
distribution width (PDW), a platelet index, indicates variation in platelet size. We aimed to investigate whether the
combination of D-dimer and PDW could have a better performance in predicting DVT in patients with cervical
carcinoma. Materials and Methods: In 198 consecutive cervical carcinoma patients without preoperative DVT,
preoperative D-dimer and PDW levels were measured. Compression ultrasonography was performed in all cervical
carcinoma patients before surgery, as well as one month, three months, six months, and 12 months. Results: During a
median period of 12 months, 17 of the 198 patients (8.6 %) developed DVT. PDW levels were reduced and D-dimer
levels were increased in patients with DVT events compared to those without DVT. Multivariate Cox analysis revealed
that both PDW and D-dimer were independent predictors for DVT events. The area under the ROC curve was 0.628
(95% CI: 0.556 to 0.695, p=0.142) when D-dimer was used alone, whereas it increased to 0.777 (95% CI: 0.712 to
0.833, p<0.011) with the addition of PDW. Incorporation of PDW into the D-dimer model significantly improved the
predictive value. Conclusions: The combination of preoperative D-dimer and PDW improves the predictive power of
postoperative DVT risk in patients with cervical carcinoma.