Document Type: Research Articles
The Graduate School, University of Santo Tomas, Manila, Philippines.
Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Philippines.
University of Santo Tomas Hospital, Benavides Cancer Institute, Manila, Philippines.
College of Science, University of Santo Tomas, Manila, Philippines.
Background: The identification of cancer-associated single nucleotide polymorphisms (SNP) and mutation
genes is a promising approach in recognizing individuals who are at risk of developing cancer. Hence, this study
was conducted to determine the association between XRCC4 c.1394G>T SNP and breast cancer development among
Filipinos. Methods: Genotyping for XRCC4 c.1394G>T SNP was performed on breast cancer patients (n=103) and
their age- and sex- matched clinically healthy controls (n=103) by polymerase chain reaction – restriction fragment
length polymorphism. Results: Significant difference in genotype (p=0.007) and allele (p=0.003) frequencies in XRCC4
c.1394G>T was observed between the breast cancer cases and controls. Carriers of the XRCC4 c.1394 G>T genotype
were observed to have significantly higher risk of developing breast cancer compared to individuals with T/T genotype
(OR=2.67, 95% CI: 1.36 – 5.25). XRCC4 c.1394G>T combined with passive smoking may also significantly increase
risk of breast cancer (OR=14.73; 95% CI= 9.88-18.86). Conclusion: XRCC4 c. 1394G>T may be associated with
breast cancer development among Filipinos.