Document Type: Research Articles
Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
City College of New York (“CCNY”), Provost and Senior Vice President for Academic Affairs, Dean of Medical School, New York.
Shiraz University of Medical Sciences, Shiraz, Iran
Background: No study to date provides evidence suggesting that lower cholesterol is associated with excess death
in non-cardiovascular disease (NCVD). This study aimed to determine the association between low cholesterol level
and NCVD mortality. Methods: A nine-year cohort study was conducted on 3,079 male and 26,005 female Italians
aged 20-69 years old. The Cox proportional hazard models implied a hazard ratio with 95% confidence interval for
association. Results: Among males, there were significant inverse associations between the lowest cholesterol decile
(< 160mg/dl) hazard ratio and all-cause deaths and non-cardiovascular deaths, 1.50 (1.19-1.89) and 2.06 (1.54-2.74),
respectively. Among females, there was a significant inverse association of lowest and fourth cholesterol deciles, 1.53
(1.01-2.34); 1.52 (1.06-2.18) hazard ratio for all-cause deaths and risk for non-cardiovascular deaths in the same deciles
1.52 (0.91-2.50); 1.78 (1.16-2.71), respectively. Remarkably, in depth analysis for NCVD, found significant inverse
associations hazard of cholesterol CVD in males and only NCLD death was significant in females. Conclusion: Among males, there were significant
inverse hazard associations between the lowest cholesterol decile and all-cause and non-CVD deaths . Among females,
there were significant inverse hazard associations of lowest and fourth cholesterol decile for all-cause and also risk first
and fourth deciles for non-CVD mortality.