The Association Between Low Serum Cholesterol and Non-Cardiovascular Mortality among Italian Males and Females: A Nine- Year Prospective Cohort Ctudy

Document Type: Research Articles

Authors

1 Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

2 City College of New York (“CCNY”), Provost and Senior Vice President for Academic Affairs, Dean of Medical School, New York.

3 Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background: No study to date provides evidence suggesting that lower cholesterol is associated with excess death
in non-cardiovascular disease (NCVD). This study aimed to determine the association between low cholesterol level
and NCVD mortality. Methods: A nine-year cohort study was conducted on 3,079 male and 26,005 female Italians
aged 20-69 years old. The Cox proportional hazard models implied a hazard ratio with 95% confidence interval for
association. Results: Among males, there were significant inverse associations between the lowest cholesterol decile
(< 160mg/dl) hazard ratio and all-cause deaths and non-cardiovascular deaths, 1.50 (1.19-1.89) and 2.06 (1.54-2.74),
respectively. Among females, there was a significant inverse association of lowest and fourth cholesterol deciles, 1.53
(1.01-2.34); 1.52 (1.06-2.18) hazard ratio for all-cause deaths and risk for non-cardiovascular deaths in the same deciles
1.52 (0.91-2.50); 1.78 (1.16-2.71), respectively. Remarkably, in depth analysis for NCVD, found significant inverse
associations hazard of cholesterol CVD in males and only NCLD death was significant in females. Conclusion: Among males, there were significant
inverse hazard associations between the lowest cholesterol decile and all-cause and non-CVD deaths . Among females,
there were significant inverse hazard associations of lowest and fourth cholesterol decile for all-cause and also risk first
and fourth deciles for non-CVD mortality.

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