Document Type: Systematic Review and Meta-analysis
Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, Cheras, Kuala Lumpur, Malaysia.
Background: Colorectal cancer (CRC) is one of the major causes of morbidity and mortality. According to
National Cancer Registry, the incidence of colorectal cancer in Peninsular Malaysia increases with age. The incidence
is highest among Chinese population but lower among Indians and Malays. Many reviews have suggested that obesity
may be associated with a higher risk (>50%) of colorectal cancer. Methods: This study collects a comprehensive
data from the literature review available from respective journals on dietary intervention and the chemo-protective
mechanisms of a few natural resources in obesity -associated colon cancer based on previous and current studies.
Results: In obesity-associated colon cancer, the genes of interest and pathways that are mainly involved include
NFκB, P13K/Akt, and MAPK pathways, and FTO, leptin, Cyclin D, MMPs, and STAT3 genes. Dietary modification
is one of the alternative steps in early prevention of colon cancer. It has been proposed that the components present in
certain foods may have the ability to protect against many diseases including the prevention of cancer. Conclusion:
There are many factors that lead to obesity-associated colon cancer and the mechanisms behind it is still undergoing
intensive research. This review aims to scrutinize research as well as reviews that have been previously reported on
obesity associated colorectal cancer and the beneficial effects of including antioxidants-rich foods such as vegetables
and fruits in the diet to reduce the risk of obesity associated colorectal cancer.