Polymeric Microsphere Formulation for Colon Targeted Delivery of 5-Fluorouracil Using Biocompatible Natural Gum Katira

Document Type : Research Articles


1 Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.

2 Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, Jalan Jalil Perkasa, Bukit Jalil, Kuala Lumpur, Malaysia.

3 Department of Pharmaceutical Science and Technology, JIS University, Kolkata, India.


Controlled release delivery system of chemotherapeutic agents at the site of colon endorses modern drug-entrapped
delivery tools, which release the entrappedagents at a controlled rate for anextended period providing patient compliance
and additional protection from the degradinggastric environment. Thus, the present study was aimed to develop
and optimize a novel polymeric microsphere of 5-fluorouracil (5-FU) using natural gum katira to obtain an optimal
therapeutic response at the colon. Due course of experimentation, in-vivo safety profile of the gum katira in an animal
model was established. Modified solvent extraction/evaporation technique wasemployed to encapsulate 5-FU in the
natural polymeric microsphere and was characterized using in-vitro studies to investigate particle size, morphology,
encapsulation efficiency and release of the drug from developed formulation. Formulated and optimized polymeric
microsphere of 5-FU using gum katira polymer own optimal physicochemical characteristics with a fine spherical particle
with size ranged from 210.37±7.50 to 314.45±7.80 μm.Targeted microsphere exhibited good cytotoxicity and also has
high drug entrapment efficiency, and satisfactory release pattern of the drug within a time frame of 12 h. Finally, we
foresee that the optimized polymeric gum katiramicrosphere of 5-FU could be a promising micro-carrier for efficient
colon drug targeting delivery tool with improved chemotherapeutic efficacy against colon cancer.


Main Subjects

Volume 20, Issue 7
July 2019
Pages 2181-2194
  • Receive Date: 07 May 2019
  • Revise Date: 03 July 2019
  • Accept Date: 14 July 2019
  • First Publish Date: 14 July 2019