In Vivo Anti Cancer Potential of Pyrogallol in Murine Model of Colon Cancer

Document Type: Research Articles

Authors

1 Department of Zoology, Periyar University, Salem 636 011, Tamil Nadu, India.

2 Department of Mathematics and Sciences, College of Arts and Applied Sciences, , Dhofar University, Salalah, Oman.

3 Research Center, Dhofar University, Salalah, Oman.

4 Insect Molecular Biology Laboratory, Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.

5 School of Pharmacy and Pharmaceutical Sciences, Saad Centre for Pharmacy and Diabetes, Ulster University, Cromore Road, Coleraine, Co. Londonderry, BT52 1SA, United Kingdom.

6 Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield, United Kingdom.

7 Department of Biotechnology, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, India.

8 Chemistry Division, Department of Basic Sciences, College of Applied and Health Sciences, Sharqiyah University, Ibra, Oman.

Abstract

Background: Colon cancer is aggressive and it causes 0.5 million deaths per year. Practicing natural medicines
for cancer treatment is safer than conventional drugs. World health organization emphasizes on the importance of
practicing natural medicines and developing natural product based drugs for cancer treatment. Recently we reported
an anti colon cancer activity associated with pyrogallol isolated from medicinal plant Acacia nilotica in HT-29 cells in
vitro. To extend our observation in this study we evaluated in vivo colon tumor remission property of acetone extract
of A. nilotica (ACE) and pyrogallol. Materials and Methods: In vivo toxicity of ACE and pyrogallol was assessed and
In vivo tumor remission activity of ACE and pyrogallol was determined in murine model. Results: Mice were tolerated
different doses of ACE and pyrogallol. Tumor size was considerably reduced in pyrogallol treated mice similar to
doxorubicin. Tumor bearing mice treated with ACE and pyrogallol showed mild decline in body weight. Conclusion:
Pyrogallol was found to be an effective anti colon cancer agent with less toxicity.

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