Stage-Specific Survival Rate of Breast Cancer Patients in Northern Thailand in Accordance with Two Different Staging Systems

Document Type: Research Articles

Authors

1 Division of Radiation Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

2 Northern Thai Research Group of Radiation Oncology (NTRG-RO), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

3 Chiang Mai Cancer Registry, Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

4 Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

5 Oncology Unit, Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

6 Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Abstract

Objective: This study was attempted to investigate overall survival by stage at diagnosis in female breast cancer
patients in Northern Thailand by using 2 different staging systems; namely, American Joint Committee on Cancer (AJCC)
Tumor (T), Nodal (N) and Metastatic (M) staging system and Surveillance Epidemiology and End Results (SEER)
summary staging system. Methods: We studies female breast cancer patients whose data were registered in Chiang Mai
cancer registries between January 2006 and December 2015. Data were recorded in SEER summary staging system.
The TNM AJCC staging was searched in the medical records. Results: A total of 3,873 female breast cancer patients
were diagnosed from 2006-2015. All data sets were recorded in SEER summary stage 2000. Early stage was the most
prevalent stage at the time of diagnosis (58%), followed by loco-regional advanced stage (32%), and metastatic breast
cancer (10%). The 5-year overall survival rate of early, loco-regional advanced, and metastatic stages were 85.3%,
66.4%, and 26.2%, respectively. After examining the medical records, we excluded patients who had no data on T, N,
and M in their records. Finally, only 3,251 patients were analyzed for AJCC stage-specific survival. The 5-year overall
survival rate in stages I, II, III, and IV were 94.4%, 85.0%, 56.6%, and 28.3%, respectively. Conclusion: Comparing
to more stable economic countries, the 5-year overall survival rate for a specific stage of breast cancer in Northern
Thailand was slightly lower in early stage and stage I-II in accordance with AJCC, but much lower in loco-regional stage
and stage III with respect to AJCC. Nevertheless, it was similar in metastatic stage and stage IV according to AJCC.

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