The Association of Dietary Intake of Calcium and Vitamin D to Colorectal Cancer Risk among Iranian Population

Document Type : Research Articles


1 Gastrointestinal and Liver Diseases Research Center (GILDRC), Iran University of Medical Sciences (IUMS), Tehran, Iran.

2 Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

3 Firoozgar Hospital, FCRDC, Iran University of Medical Sciences, Tehran, Iran.

4 Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.

5 Department of Epidemiology and Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran.


Background: Vitamin D and Calcium have a possible protective impact versus rectal neoplasm. Vitamin D, an
important nutrient, is vital to regulate the absorption of calcium and bone mineralization; nevertheless, in a case-control
study in Iran, we investigated the relationship among the dietary intake of vitamin D and calcium with the hazard of
rectal neoplasm. Methods: 363 subjects (162 cases and 201 controls) participated in the case- control Study from
March 2017 to November 2018. Dietary intake of Calcium and Vitamin D was calculated using a 148-items foodfrequency
questionnaire. Results: Since altering the strong confounding agents, the multivariate risk proportion within
the dietary vitamin D intake was OR=0.2, 95%CI 0.1-0.5, P_value case of calcium and rectal cancer. Conclusions: Taken together, a possible reduction in the hazard of rectal neoplasm
with dietary intake of Vitamin D within Iranian patients was observed.


Main Subjects

Volume 20, Issue 9
September 2019
Pages 2825-2830
  • Receive Date: 14 July 2019
  • Revise Date: 02 September 2019
  • Accept Date: 12 September 2019
  • First Publish Date: 12 September 2019