Association of CYP1A1 rs1048943 Polymorphism with Prostate Cancer in Iraqi Men Patients

Document Type: Research Articles

Authors

1 Department of Chemistry, College of Education, University of Al-Qadisiyah, Al-Qadisiyah City, Iraq.

2 Department of Biochemistry, College of Medicine, University of Al-Qadisiyah, Al-Qadisiyah City, Iraq.

3 Department of Medical Biotechnology, College of Biotechnology, University of Al-Qadisiyah, Al-Qadisiyah City, Iraq.

Abstract

Objective: The purpose of this study was to evaluate the relationship between CYP1A1 gene rs1048943 polymorphism and the risk of Iraqi men with prostate cancer. Methods: In this research, we conducted a population-based approach that intersects high-throughput genotype information from  different population of Iraq to estimate the frequency of genotypes associated with prostate cancer responsivenessOur study included a total of 100 patients and 150 healthy controls. rs1048943 genotyping has been investigated in Iraqi men in connection with prostate cancer. Results: We observed that individuals with the rs1048943 GA genotype had an increased risk of prostate cancer relative to those with the AA genotype  ( OR 95% CI of 0.449 :95%CI 0.23-0.90; P = 0.002). We found in the dominant model that the rs1048943 GA and GG genotype displayed an increased risk of prostate cancer relative to the AA genotype   ( OR 95% CI of 0.680 :95%CI 0.4-1.17; P = 0.018). Conclusion: Polymorphism RS 1048943 in the CYP1A1 gene is associated with the risk of developing prostate cancer and is possibly one of the most significant factors in its development.
 

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