Association of CYP1A1 rs1048943 Polymorphism with Prostate Cancer in Iraqi Men Patients

Document Type : Research Articles

Authors

1 Department of Chemistry, College of Education, University of Al-Qadisiyah, Al-Qadisiyah City, Iraq.

2 Department of Biochemistry, College of Medicine, University of Al-Qadisiyah, Al-Qadisiyah City, Iraq.

3 Department of Medical Biotechnology, College of Biotechnology, University of Al-Qadisiyah, Al-Qadisiyah City, Iraq.

Abstract

Objective: The purpose of this study was to evaluate the relationship between CYP1A1 gene rs1048943 polymorphism and the risk of Iraqi men with prostate cancer. Methods: In this research, we conducted a population-based approach that intersects high-throughput genotype information from  different population of Iraq to estimate the frequency of genotypes associated with prostate cancer responsivenessOur study included a total of 100 patients and 150 healthy controls. rs1048943 genotyping has been investigated in Iraqi men in connection with prostate cancer. Results: We observed that individuals with the rs1048943 GA genotype had an increased risk of prostate cancer relative to those with the AA genotype  ( OR 95% CI of 0.449 :95%CI 0.23-0.90; P = 0.002). We found in the dominant model that the rs1048943 GA and GG genotype displayed an increased risk of prostate cancer relative to the AA genotype   ( OR 95% CI of 0.680 :95%CI 0.4-1.17; P = 0.018). Conclusion: Polymorphism RS 1048943 in the CYP1A1 gene is associated with the risk of developing prostate cancer and is possibly one of the most significant factors in its development.
 

Keywords

Asian Pacific Journal of Cancer Prevention
Volume 20, Issue 12
December 2019
Pages 3839-3842

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History

  • Receive Date: 18 October 2019
  • Revise Date: 28 October 2019
  • Accept Date: 19 November 2019

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