LncRNAs as Potential Therapeutic Targets in Thyroid Cancer

Document Type: Systematic Review and Meta-analysis

Authors

1 Office for Research Innovation and Commercialization Lahore Garrison University, Lahore, Pakistan.

2 Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan.

3 Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

4 Institute of Biochemistry and Biotechnology,University of Veterinary and Animal Sciences, Lahore, Pakistan.

5 Center for Excellence in Molecular Biology, University of the Punjab Lahore, Lahore, Pakistan.

6 Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam, Iran.

7 Department of Medical Parasitology, Kerman University of Medical Sciences, Kerman, Iran.

8 OU Endocrinology, Dept. Medicine (DIMED), University of Padova, via Ospedale 105, 35128 Padova, Italy.

9 AIROB, Associazione Italiana per la Ricerca Oncologica di Base, Padova, Italy.

10 Department of Agricultural and Environmental Sciences, Milan State University, 20133 Milan, Italy.

11 Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

12 Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong, China.

Abstract

Thyroid cancer (TC) is the most common cancer of endocrine system. TC can be subdivided into 4 different entities, papillary, follicular, medullary and anaplastic thyroid cancer. Among them, anaplastic thyroid cancer has the poorest prognosis. Exploring new therapeutic approach may entail favorable prediction as well as increasing overall survival rate of patients. Long non-coding RNAs (lncRNAs), have vast implications in different cancer types. Although they are not transcribed into proteins, they can act as a harness in regulating a plethora of biological functions. They have been implicated in a decisive role in gene expression via modulation of both coding and non-coding RNAs. This article discuss the multi-facet role of lncRNA in thyroid cancer biology.
 

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