Document Type: Research Articles
Department of Surgery, Shiga University of Medical Science, Otsu, Japan.
Department of Surgery, Kansai Medical University, Hirakata, Japan.
Department of General and Gastroenterological Surgery, Osaka Medical College, Takatsuki, Japan.
Second Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Department of Surgery, Nara Medical University, Kashihara, Japan.
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.
Department of Surgery, Faculty of Medicine, Kinki University, Osaka-sasayama, Japan.
Background: Hepatic resection (HR) is not recommended for intermediate-stage hepatocellular carcinoma (HCC) by the Barcelona Clinic Liver Cancer criteria. We examined the prognostic factors of HR for intermediate-stage HCC and developed new HR criteria for intermediate-stage HCC. Methods: A total of 110 patients who underwent HR without any prior treatment for intermediate-stage HCC between January 2007 and December 2012 were enrolled at eight university hospitals. The outcomes and prognostic factors of HR were evaluated to develop new HR criteria. Results: In terms of tumor size and number, the most significant prognostic factors were within the up-to-seven criteria. Furthermore, serum albumin level ≥35 g/L and serum alpha-fetoprotein (AFP) level