Evaluation of Mast Cell Density using CD117 antibody and Microvessel Density Using CD34 Antibody in Different Grades of Oral Squamous Cell Carcinoma

Document Type: Research Articles

Authors

1 Department of Histopathology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan.

2 Consultant Histopathologist, Armed Forces Institute of Pathology, Rawalpindi, Pakistan.

3 Department of Oral Pathology, Army Medical College, Rawalpindi, Pakistan.

4 Department of Orthodontics, Armed Forces Institute of Dentistry, Rawalpindi, Pakistan.

Abstract

Objective: To compare mast cell and microvessel densities among histologic grades of oral squamous cell carcinoma. Setting: Armed Forces Institute of Pathology. Materials and Methods: A total of 60 specimens of OSCC comprising 20 each of well, moderately and poorly differentiated were evaluated. Immunohistochemical analysis was performed to measure MCD and MVD by applying monoclonal CD117 antibody and monoclonal CD34 antibody, on formalin fixed and paraffin embedded sections. ANOVA and Post Hoc Tukey test was employed to assess the densities and to compare the differences between different grades of OSCC. A p-value  

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