Document Type : Research Articles
Department of Medical Laboratory Technology, Faculty of Applied Medical Science, Jazan University, Saudi Arabia.
Department of Medicine, University Of Cambridge, United Kingdom.
Massachusetts General Hospital Cancer Centre, Harvard Medical School, USA.
Emergency Medical Services, Jazan University, Saudi Arabia.
King Fahad Medical City, Riyadh, Saudi Arabia.
Objectives: The association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the development of type 2 diabetes mellitus (T2DM) has been debated vigorously but still remains controversial. Therefore, the current study was designed to determine the possible association between ACE I/D polymorphism and T2DM and hypertension (HTN) in a population of Saudi Arabian participants. Methods: A total of 143 individuals were recruited for the study, consisting of 74 controls and 69 patients with T2DM. Genotyping was performed via polymerase chain reaction. Results: The genotype frequencies for DD, ID and II in controls were 52.7%, 39.2% and 8.1%, whereas in T2D patients it was 52.2%, 40.6% and 7.2% respectively. The DD frequency was highest out of the three genotypes in both the controls and the T2DM patients. Conclusion: There was no significant difference found in the genotype and allele frequencies between cases and controls, suggesting that insertion/deletion polymorphism in the ACE gene may not be associated with an increased susceptibility to type 2 diabetes in our study population.