Evaluation of Cortactin and HS1 Genes Expression: New Players in Adult B-Cell Acute Lymphoblastic leukemia

Document Type: Research Articles

Authors

1 Hematology Unit, Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Egypt.

2 Medical Oncology Unit, Mansoura University Oncology Center (MUOC) Mansoura University, Egypt.

3 Hematology Unit, Mansoura University Oncology Center (MUOC), Mansoura University, Egypt.

Abstract

Objectives: This study aimed to assess the prognostic value of cortactin and HS1 genes expression in adult B-cell acute lymphoblastic leukemia. Methods: The study included a cohort of 74 adult B-ALL patients and 76 controls. Cortactin and HS1 genes expression were quantified by real time PCR. Results: The expression of cortactin and HS1 were significantly higher in B-ALL patients at diagnosis as compared to post induction levels (p

Keywords

Main Subjects