Determination of Pentraxin-3, Interleukin-8 and Vascular Endothelial Growth Factor Levels in Patients with Gastric Adenocarcinoma

Yeni, Mustafa; Korkut, Ercan; Aksungur, Nurhak; Kara, Salih; Askin, Seda; Kartal, Murat

doi:10.31557/APJCP.2021.22.5.1507

Determination of Pentraxin-3, Interleukin-8 and Vascular Endothelial Growth Factor Levels in Patients with Gastric Adenocarcinoma

Document Type : Research Articles

Authors

¹ General Surgery Clinic, Regional Training and Research Hospital, Erzurum, Turkey.

² Department of General Surgery, Atatürk University Faculty of Medicine, Erzurum, Turkey.

³ General Surgery, Faculty of Medicine, Ataturk University, Erzurum, Turkey.

⁴ Department of Biochemistry, Atatürk University, Erzurum, Turkey.

⁵ Department of General Surgery, Erzurum Regional Training Research Hospital, Erzurum, Turkey.

10.31557/APJCP.2021.22.5.1507

Abstract

Introduction and Aim: The purpose of this study was to determine the value, in terms of diagnosis, resectability and prognosis of pentraxin-3 (PTX3), interleukin-8 (IL-8) and vascular endothelial growth factor (VEGF) in cases of gastric adenocarcinoma, an important condition both worldwide and in Turkey, and to determine their levels in order to contribute to elucidating the pathogenesis of the disease. Materials and Methods: Serum was separated from blood specimens collected from 45 patients diagnosed with gastric adenocarcinoma and from a 30-member healthy control group. Serum PTX3, IL-8 and VEGF levels were studied by ELISA method. Results: Serum PTX3 values differed significantly between the patient group and the control group (p <0.05). Serum IL-8 values also differed significantly between the patient group and the control group (p <0.05). A significant difference was also observed between serum VEGF values in the patient group and the control group (p <0.05). Significant correlation was determined between serum PTX3 and VEGF (p <0.01; r=0.833), between serum PTX3 and IL-8 (p <0.01; r=0.818), and between serum VEGF and IL-8 (p <0.01; r=0.803), measurements when the entire study population was evaluated irrespectively of groups. Conclusion: Serum PTX3, IL-8 and VEGF levels decreased in cases of gastric adenocarcinoma compared to the control group, and their levels affected one another.

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