Association of IL-6 -174G>C and -572G>C Polymorphisms with Susceptibility to Cervical Cancer and Ovarian Cancer

Document Type : Research Articles

Authors

1 Department of Pharmaceutics, Faculty of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran.

2 Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.

3 Department of Obstetrics and Gynecology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.

4 Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

5 Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran.

6 Department of Genetics, Marvdasht Branch, Azad University, Marvdasht, Iran.

7 Biotechnology Research Center, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

8 Student of Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

9 Department of Anatomy School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

10 Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

11 Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Abstract

Background: During the past decades, the expansion of molecular development has had a key role in understanding the basis of gynecological cancer. Interleukin-6 (IL-6) is known to be involved in the pathogenesis of different cancers. Here, we evaluated the association of IL-6 -174G>C and -572 G>C polymorphisms with susceptibility to cervical and ovarian cancers in an Iranian population. Methods: A total of 131 cases with ovarian cancer, 124 cases with cervical cancer and 140 healthy subjects were enrolled to the study. DNA was extracted from peripheral blood cells of subjects to genotype the IL-6 -174G>C and -572 G>C polymorphisms by amplification refractory mutation system (RFLP) polymerase chain reaction (PCR). Results: There was a significant association of IL-6 -174G>C CC genotype (OR= 3.231, 95% CI: 1.130-9.239, p=0.029) and C allele (OR = 1.915; 95%CI: 1.266-2.896, p=0.002) with an increased risk of ovarian cancer. Moreover, the IL-6 -174G>C CC genotype (OR= 3.162, 95% CI: 1.094-9.141, p=0.034) and C allele (OR = 1.724; 95%CI: 1.129-2.633, p=0.012) was associated with increased risk of cervical cancer. Conclusions: This study showed that the IL-6 -174G>C polymorphism was associated with ovarian cancer and cervical cancer risk. However, IL-6 -572 G>C polymorphism was not associated.

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Volume 22, Issue 9
September 2021
Pages 2867-2871
  • Receive Date: 27 May 2021
  • Revise Date: 04 June 2021
  • Accept Date: 10 September 2021
  • First Publish Date: 10 September 2021