Geographic Variability of Gastric Cancer Incidence in Kazakhstan

Document Type : Research Articles

Authors

1 Astana Medical University, Nur-Sultan, Kazakhstan.

2 Central Asian Institute for Medical Research, Nur-Sultan, Kazakhstan.

3 Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan.

4 Khoja Akhmet Yassawi International Kazakh-Turkish University, Shymkent Campus, Kazakhstan.

5 Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.

6 Institute of Clinical and Preventive Medicine, University of Latvia, Riga, Latvia.

7 Faculty of Medicine, University of Latvia, Riga, Latvia.

8 Riga East University Hospital, Riga, Latvia.

9 Digestive Disease Centre GASTRO, Riga, Latvia.

10 Eurasian Institute for Cancer Research, Bishkek, Kyrgyzstan.

Abstract

Objective: The article studies the geographical features of the incidence of gastric cancer (GC) in Kazakhstan. Methods: The retrospective study was done for the period 2009-2018. Descriptive and analytical methods of oncoepidemiology were used. Crude (CR), age-specific (ASIR), age-standardized (ASR), equalized incidence rates and approximation were calculated. The dynamics of indicators was investigated using component analysis according to methodological recommendations. The method of drawing up a cartogram based on the determination of the standard deviation (σ) from the mean (x) was applied. Results: During the study period, 27,467 new cases of GC were registered. The incidence rate increased from 16.80 (2009) to 15.10 in 2018 and the overall decline was 1.70 per 100,000 population, including due to the age structure – ∑ΔA=+1.51, due to the risk of acquiring illness – ∑ΔR=−2.91 and their combined effect – ∑ΔRA=−0.31. The component analysis revealed that the increase in the number of patients with GC was mainly due to the growth of the population (ΔP=+651.8%), changes in its age structure (ΔA=+433.9%) and changes associated with the risk of acquiring illness (ΔR=−832.1%). The cartograms were allocated according to the following criteria: low – up to 14.80/0000, average – from 14.8 to 19.20/0000, high – above 19.20/0000. The results of the spatial assessment showed the highest levels of GC incidence in following regions: Akmola (22.20/0000), North Kazakhstan (22.30/0000), and Pavlodar (23.20/0000). Conclusion: Thus, as a result of the epidemiological analysis, the role of the influence of demographic factors and the risk of acquiring illness on the formation of the number of patients and the incidence of GC was evaluated, while sex differences and geographical variability were established.

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Volume 23, Issue 6
June 2022
Pages 1935-1944
  • Receive Date: 21 October 2021
  • Revise Date: 06 April 2022
  • Accept Date: 13 June 2022
  • First Publish Date: 13 June 2022