Prognostic Role of Oncogenic and Tumor-Suppressing miRNA Types in Egyptian Uterine Cancer Patients

Salim, Elsayed I; Beltagy, Doha M; Elmashad, Nehal M; Abodonia, Mohamed A

doi:10.31557/APJCP.2022.23.8.2607

Prognostic Role of Oncogenic and Tumor-Suppressing miRNA Types in Egyptian Uterine Cancer Patients

Document Type : Research Articles

Authors

¹ Department of Zoology, Research Lab. for Molecular Carcinogenesis, Faculty of Science, Tanta University, Tanta 31527, Egypt.

² Department of Chemistry, Biochemistry Division, Faculty of Science, Damanhour University, Damanhour 22516, Egypt.

³ Department of Clinical Oncology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.

10.31557/APJCP.2022.23.8.2607

Abstract

Objective: Uterine or endometrial cancer affects many women postmenopausal and may reach an advanced stage before signs and symptoms can be noticed. Micro RNAs (miRNAs), non-coding RNAs, play key roles in gene expression regulation and are linked to cancer. This study aimed to elucidate whether some specific types of miRNAs (miRNA133-a, miRNA-21, miRNA-205) can act as prognostic or diagnostic biomarkers for endometrial carcinoma (ER) in Egyptian patients. Methods: Blood samples from 36 patients suffering from endometrial carcinoma and 15 healthy volunteers were tested for expression levels of miRNA 133a-2, 21 and 205. Results: The expression levels of miRNA133a-2, miRNA-21, and miRNA-205 were significantly elevated in ER patients when compared with the control group, the highest levels were noticed in miRNA133a-2. The CA125 levels were significantly higher in all patients as compared with healthy subjects. Conclusion: The findings could support the use of circulating miR133a-2, miR-21 and miR-205 as virtuous prognostic biomarkers for EC in Egyptian patients. The studied miRNA species warrant validation for prospective targeting inhibitory protocols in EC.

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