Document Type : Research Articles
Doctoral Program, Department of Chemistry, Faculty of Mathematics, and Natural Science, Hasanuddin University Makassar, Indonesia.
Department of Biology Education, Faculty of Teacher Training and Education, Universitas Puangrimaggalatung, Sengkang, Indonesia.
Department of Chemistry, Faculty of Mathematics, and Natural Science, Hasanuddin University Makassar, Indonesia.
Solar Energy Research Institute, Universiti Kebangsaan Malaysia 43600 UKM Bangi, Selangor, Malaysia.
Research Centre for Electrical Power and Mechatronics, Institute of Science (LIPI), Bandung, Indonesia.
Department of Pharmacy, Faculty of Medical Science, Universitas Ibrahimy, Situbondo, East Java, Indonesia.
Medical Laboratory Technology, Faculty of Health Technology, Megarezky University, Makassar, Indonesia.
Department of Surgery, Faculty of Medical, Hasanuddin University, Makassar, Indonesia.
Background: This study was carried out to synthesize a new complex of Fe(II) with isoleucine dithiocarbamate ligand and to determine its potential as an anticancer and antiviral agent for SARSCOV-2. Methods: The synthesized complexes were then characterized by UV-vis and FT-IR spectroscopy and their melting points. The value of the conductivity of the complex compound is also determined. Anti-cancer activity was tested in vitro and molecular docking. Its potential as an antiviral against SARSCOV-2 was also carried out by molecular docking. Pharmacokinetics/ADMET properties were also carried out on the complex. Result: Spectral results showed the successful synthesis of Fe(II) isoleucine dithiocarbamate complex. The complex produced UV-vis spectra at 268 and 575 nm, and the IR data at 399–599 cm-1 showed the coordination between the Fe(II) atoms with sulphur, nitrogen and oxygen of the isoleucine dithiocarbamate ligand. Fe(II) isoleucine dithiocarbamate had a cytotoxicity effect on the MCF-7 cell line (IC50 =613 µg/mL). The complex significantly caused morphological changes in the breast cancer cell line, finally leading to cell apoptosis. Conclusion: Cytotoxic test of Fe(II) isoleucine dithiocarbamate showed moderate anticancer activity on MCF-7 cancer cells and showed antiviral activity against SARSCOV-2 by interfering with spike glycoprotein –ACE2 receptors, and inhibiting major proteases and 3Clpro.