The Impact of BRCA1 Expression on Survival Status in Ovarian Serous Carcinoma of Egyptian Patients

Document Type : Research Articles

Authors

1 Department of Pathology, National Cancer Institute, Cairo University, Egypt.

2 Department of Medical Oncology, National Cancer Institute, Cairo University, Egypt.

Abstract

Objectives: The present study aimed to investigate the impact of BRCA1 protein expression on the patients’ outcome of ovarian serous carcinoma, and its correlation with different clinicopathologic features. Methods: Immunohistochemistry with BRCA1 was done for 80 cases of ovarian serous carcinoma that had a positive family history. Correlation with clinico-pathologic variables and patients’ outcomes was investigated. Results: BRCA1 expression was detected in 61.2% of the studied cases. A significant relation with patients’ age, tumor grade and tumor stage was found (P<0.05). Also, there was a significant decrease in disease free survival (DFS) & overall survival (OS) in the positive BRCA1 group. Metastasis, recurrence, residual disease, and mortality rate showed significantly higher figures in patient with BRCA1 expression (P<0.05). Conclusion: Positive BRCA1 expression had proven to be associated with advanced stage & grade of tumors, as well as worsened prognostic survival parameters (metastasis, recurrence, residual disease, and mortality) in patients with ovarian serous carcinoma.

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Asian Pacific Journal of Cancer Prevention
Volume 24, Issue 10
October 2023
Pages 3613-3620

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History

  • Receive Date: 05 July 2023
  • Revise Date: 24 August 2023
  • Accept Date: 12 October 2023

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