Lack of Association between TP73 G4C14-A4T14 Polymorphism and Cervical Cancer Risk in Overall and Asian Women: A Meta-Analysis

Document Type : Research Articles

Authors

1 Department of Obstetrics and Gynecology, Firoozgar Clinical Research Development Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.

2 Department of Obstetrics and Gynecology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

3 Department of Gynecologic Oncology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.

4 Department of Obstetrics and Gynecology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.

5 Department of Surgery, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

6 Shahid Akbarabadi Clinical Research Development Unit, Iran University of Medical Sciences, Tehran, Iran.

7 Department of Radiation Oncology, Firoozgar Clinical Research Development Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.

8 Department of Obstetrics and Gynecology, Iranshahr University of Medical Sciences, Iranshahr, Iran.

9 Department of Cancer Biology, College of Medicine, University of Cincinnati, Ohio, USA.

10 Hematology and Oncology Research Center, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

11 Department of Radiology, Shahid Rahnemoun Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

12 Mother and Newborn Health Research Center, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Abstract

Background: Growing studies revealed the association between polymorphisms in Tumor Protein TP73 (TP73) and susceptibility to cancer, especially with gynecological cancers. but, the results remained inconsistent. This meta-analysis was carried out to examine the relationship of the TP73 G4C14-to-A4T14 polymorphism (hereafter, G4C14-to-A4T14) with susceptibility to cervical cancer globally and by ethnicity. Methods: Eligible studies were collected by retrieving PubMed, Scopus, Web of Science, Embase, Wan Fang, and CNKI published before 25 October, 2023. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of such association. Results: A total of 10 case-control studies with 1804 cervical cancer cases and 2433 healthy controls were included to this study. The pooled results showed that TP73 G4C14-to-A4T14 polymorphism was not associated with cervical cancer risk in overall. in terms of stratified analyses by ethnicity, this polymorphism was not associated with risk of cervical cancer among East-Asian women. however,  there was a significant association based source of control among hospital-based studies.Conclusions: Inconsistent with previous meta-analyses, our pooled results revealed that TP73 G4C14-to-A4T14 polymorphism might not be a risk factor for development of cervical cancer globally and among East-Asian women. Moreover, further studies examining the effect of gene-gene and gene-environment interactions may eventually provide a better knowledge.

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Asian Pacific Journal of Cancer Prevention
Volume 25, Issue 2
February 2024
Pages 661-670

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History

  • Receive Date: 22 October 2023
  • Revise Date: 09 December 2023
  • Accept Date: 19 February 2024

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