@article { author = {Kong, Moonkyoo and Lim, Yu Jin and Kim, Youngkyong}, title = {Concurrent Chemoradiotherapy for Loco-regionally Advanced Nasopharyngeal Carcinoma: Treatment Outcomes and Prognostic Factors}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {19}, number = {6}, pages = {1591-1599}, year = {2018}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.22034/APJCP.2018.19.6.1591}, abstract = {Background: We conducted this study to contribute to resolving some controversial issues on management ofnasopharyngeal carcinoma. Methods: Thirty-two patients with stage III-IVB nasopharyngeal carcinoma were includedin this retrospective study. All patients received concurrent chemoradiotherapy with either 3D conformal radiotherapyor intensity-modulated radiotherapy. We retrospectively analyzed the survival outcome, prognostic factors for survival,and toxicity outcome. Results: The 2- and 5-year overall survival rates were 89.9% and 82.6%. The 2- and 5-yeardistant metastasis-free survival rates were 83.2% and 79.4%. The 2- and 5-year loco-regional recurrence-free survivalrates were 83.3% and 79.5%. Addition of induction chemotherapy to concurrent chemoradiotherapy did not improvesurvival outcomes. The survival benefit of intensity-modulated radiotherapy over 3D conformal radiotherapy was notclear. Intensity-modulated radiotherapy significantly decreased the development of late toxicities compared with 3Dconformal radiotherapy. Total RT dose was prognostic factor for overall, loco-regional recurrence-free, and distantmetastasis-free survival. Temporary RT interruption was prognostic factor for overall survival. Daily RT dose wasprognostic factor for distant metastasis-free survival. Conclusions: Concurrent chemoradiotherapy resulted in highsurvival rates with an acceptable level of toxicities in patients with loco-regionally advanced nasopharyngeal carcinoma.To confirm the results of this study, well-designed randomized prospective trials are warranted.}, keywords = {Nasopharyngeal carcinoma,radiotherapy,survival}, url = {https://journal.waocp.org/article_63021.html}, eprint = {https://journal.waocp.org/article_63021_f06f26e11473165fe9da4635040aab37.pdf} }