@article { author = {Feizy, Abdolamir and Karami, Aida and Eghdamzamiri, Reza and Moghimi, Minoosh and Taheri, Hadi and Mousavinasab, Nouraddin}, title = {HER2 Expression Status and Prognostic, Diagnostic, and Demographic Properties of Patients with Gastric Cancer: a Single Center Cohort Study from Iran}, journal = {Asian Pacific Journal of Cancer Prevention}, volume = {19}, number = {6}, pages = {1721-1725}, year = {2018}, publisher = {West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter.}, issn = {1513-7368}, eissn = {2476-762X}, doi = {10.22034/APJCP.2018.19.6.1721}, abstract = {Background: The fourth most prevalent cancer worldwide and a major cause of death in developing countries isgastric cancer (GC). Human epidermal growth factor receptor 2 (HER2), is a proto-oncogene expressed in differentsolid tumors. This study aimed to evaluate possible associations of HER2 expression status with survival rate, age,sex, tumor grade, histopathological type, and primary tumor location in patients with GC. Methods: Subjects wereenrolled in this cohort study after consideration of inclusion and exclusion criteria. Biopsy specimens were stained usingimmunohistochemistry. Samples with a score of 3+ were considered to exhibit HER2 overexpression. The mentionedvariables were extracted from patients’ files as well as by clinical evaluation. The Kaplan-Meier method was appliedfor analyzing the survival rate and Chi square for possible factor associations. Results: A total of 210 patients (25.2%female and 74.8% male) were enrolled. In a 5-year follow-up (adherence rate: 45.7%), the average survival was 9.4±10.9months. HER2 overexpression was evident in 24%. There was no statistically significant association found betweenHER2 expression and primary tumor location (p-value=0.63), histopathological type (p-value=0.72), or tumor grade(p-value=0.051). Furthermore, no statistically significant links were apparent with tumor grade in either male or femalegroups as well as patients aged ≥60 and ˂60 years (all p-values >0.05). Moreover, no statistically significant associationwas detected between HER2 expression status (p-value=0.88), sex (p-value=0.31), and age (p-value=0.055) with patientsurvival. Conclusions: No statistically meaningful association was found between all parameters examined and HER2expression status. Divergence of the results from earlier studies might be due to genetic variation. Thus, performing ameta-analysis on certain races might be helpful for clarification.}, keywords = {Keywords: HER2,Stomach Neoplasm,survival,Cohort studies,Iran}, url = {https://journal.waocp.org/article_63825.html}, eprint = {https://journal.waocp.org/article_63825_6a7bce7475e73a6b4bdf189e994cc16f.pdf} }